PMID- 10193326
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20190501
IS  - 0021-9746 (Print)
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 51
IP  - 11
DP  - 1998 Nov
TI  - Schwannoma with features mimicking neuroblastoma: report of two cases with 
      immunohistochemical and ultrastructural findings.
PG  - 842-5
AB  - OBJECTIVE: A study of two cases of a rare variant of benign schwannoma showing 
      areas mimicking neuroblastoma/peripheral primitive neuroectodermal tumour (PNET). 
      METHODS: Sections of formalin fixed, paraffin embedded specimens were studied by 
      tinctorial stains and immunohistochemistry, and the tissue retrieved from 
      formalin was examined by electronmicroscopy in one case. RESULTS: The tumours 
      were small and subcutaneous. Both showed features of benign schwannoma; one had a 
      multinodular plexiform pattern. In addition, rosette-like structures consisting 
      of collagenous cores surrounded by small round cells or slightly larger 
      epithelioid cells were present. Tumour cells were positive for S100 protein, 
      Leu7, and in one case GFAP, but were negative for neurofilament protein, 
      synaptophysin, and MIC2. Type IV collagen surrounded individual cells. 
      Electronmicroscopy in case 2 confirmed schwannian features (lamina, processes) 
      and failed to show features of neuroblastoma (neuroendocrine granules). 
      CONCLUSIONS: Benign schwannomas may contain rosette-like structures mimicking 
      neuroblastoma/PNET. The techniques used confirmed schwannian differentiation only 
      and eliminated neuroblastoma/PNET. These uncommon variants should be recognised 
      by practising histopathologists to avoid erroneous diagnoses and inappropriate 
      treatment.
FAU - Bhatnagar, S
AU  - Bhatnagar S
AD  - Department of Pathology, Christie Hospital, Manchester, UK.
FAU - Banerjee, S S
AU  - Banerjee SS
FAU - Mene, A R
AU  - Mene AR
FAU - Prescott, R J
AU  - Prescott RJ
FAU - Eyden, B P
AU  - Eyden BP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Middle Aged
MH  - Neurilemmoma/*pathology/ultrastructure
MH  - Neuroblastoma/*pathology
PMC - PMC500979
EDAT- 1999/04/08 00:00
MHDA- 1999/04/08 00:01
PMCR- 2001/11/01
CRDT- 1999/04/08 00:00
PHST- 1999/04/08 00:00 [pubmed]
PHST- 1999/04/08 00:01 [medline]
PHST- 1999/04/08 00:00 [entrez]
PHST- 2001/11/01 00:00 [pmc-release]
AID - 10.1136/jcp.51.11.842 [doi]
PST - ppublish
SO  - J Clin Pathol. 1998 Nov;51(11):842-5. doi: 10.1136/jcp.51.11.842.