PMID- 10193522
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20190503
IS  - 1366-8714 (Print)
IS  - 1472-4154 (Electronic)
IS  - 1366-8714 (Linking)
VI  - 51
IP  - 5
DP  - 1998 Oct
TI  - The monocyte chemotactic protein a (MCP-1) and interleukin 8 (IL-8) in Hodgkin's 
      disease and in solid tumours.
PG  - 273-6
AB  - AIMS: Monocyte chemotactic protein 1 (MCP-1) and interleukin 8 (IL-8) are small, 
      inducible proteins with chemotactic activity for specific subsets of leucocytes. 
      The possibility that MCP-1 and IL-8 are produced in tissues involved by Hodgkin's 
      disease, thus contributing to the inflammatory-type background of the lesion, was 
      investigated. METHODS: The presence of RNA transcripts for MCP-1 and IL-8 was 
      investigated in biopsy samples of 24 cases of Hodgkin's disease, 17 non-Hodgkin's 
      malignant lymphomas, 30 solid tumours, and 30 histologically normal tissues by 
      means of reverse transcription-polymerase chain reaction (RT-PCR)/Southern blot 
      analysis. RESULTS: MCP-1 expression was detected in 23 of 24 cases of Hodgkin's 
      disease, in seven of 17 cases of B cell non-Hodgkin's lymphoma, and in seven of 
      14 cases of reactive lymphoid hyperplasia. IL-8 was present in six of 14 cases of 
      Hodgkin's disease, and was seen only rarely in B cell non-Hodgkin's lymphoma and 
      in reactive lymphoid tissues. MCP-1 and IL-8 RNA transcripts were detected in 13 
      of 25 carcinomas originating from the lung, breast, thyroid, and ovary. 
      CONCLUSIONS: These findings are consistent with the possibility that MCP-1 and 
      IL-8 are two additional cytokines involved in the pathogenesis of Hodgkin's 
      disease.
FAU - Luciani, M G
AU  - Luciani MG
AD  - Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma, 
      Italy.
FAU - Stoppacciaro, A
AU  - Stoppacciaro A
FAU - Peri, G
AU  - Peri G
FAU - Mantovani, A
AU  - Mantovani A
FAU - Ruco, L P
AU  - Ruco LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Pathol
JT  - Molecular pathology : MP
JID - 9706282
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Acta Haematol. 2016;136(1):52-61. PMID: 27160311
MH  - Blotting, Southern
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Female
MH  - Hodgkin Disease/*immunology
MH  - Humans
MH  - Interleukin-8/genetics/*metabolism
MH  - Lymphoma, B-Cell/immunology
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Neoplasms/immunology
MH  - RNA, Messenger/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC395651
EDAT- 1999/04/08 00:00
MHDA- 1999/04/08 00:01
PMCR- 1998/10/01
CRDT- 1999/04/08 00:00
PHST- 1999/04/08 00:00 [pubmed]
PHST- 1999/04/08 00:01 [medline]
PHST- 1999/04/08 00:00 [entrez]
PHST- 1998/10/01 00:00 [pmc-release]
AID - 10.1136/mp.51.5.273 [doi]
PST - ppublish
SO  - Mol Pathol. 1998 Oct;51(5):273-6. doi: 10.1136/mp.51.5.273.