PMID- 10193551
OWN - NLM
STAT- MEDLINE
DCOM- 19990609
LR  - 20190826
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 25
IP  - 2
DP  - 1999 Feb
TI  - Extravascular lung water and intrathoracic blood volume: double versus single 
      indicator dilution technique.
PG  - 216-9
AB  - OBJECTIVE: The accuracy of single thermodilution was assessed in measuring 
      extravascular lung water (EVLW) and intrathoracic blood volume (ITBV). DESIGN: 
      Single thermodilution (ST) was prospectively compared with thermo-dye dilution 
      (TD) in 13 mechanically ventilated pigs using the Pulsion Cold Z-021 monitor. 
      INTERVENTIONS: Lung injury was induced with oleic acid injection. RESULTS: 
      EVLWI(TD) increased from 4.3 +/- 1.4 to 11.3 +/- 4.5 ml/kg (p = 0.0014) and 
      ITBV(TD) decreased from 581 +/- 66 to 540 +/- 85 ml (p = 0.039) after induction 
      of lung injury. EVLW(ST) was systematically overestimated (0.5-1 ml/kg) and 
      ITBV(ST) was slightly underestimated (15-20 ml) when calculated automatically by 
      the Pulsion Cold Z-021 monitor. This bias could be removed by adjusting two 
      coefficients needed for the computation of ITBV(ST) and EVLW(ST) so that the 
      following regression equations were obtained: EVLWI(ST) = 0.98 EVLWI(TD) + 0.27 
      (r = 0.94, p < 10(-6)) and ITBV(ST) = 1.0 x ITBV(TD) + 0 (r = 0.87, p < 10(-6)). 
      CONCLUSIONS: Single thermodilution allows estimation of ITBV and EVLW values with 
      reasonable accuracy and therefore provides useful information about the cardiac 
      preload and the severity of lung injury. However, automatic calculation of 
      EVLWI(ST) and ITBV(ST) using the Pulsion Cold Z-021 might be biased. Therefore, 
      researchers and clinicians should validate single thermodilution for the given 
      settings, before employing this method to estimate EVLW and ITBV.
FAU - Neumann, P
AU  - Neumann P
AD  - Department of Clinical Physiology, University of Uppsala, Sweden. pneuman@gwdg.de
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Animals
MH  - *Blood Volume
MH  - *Dye Dilution Technique
MH  - *Extravascular Lung Water
MH  - Hemodynamics
MH  - Lung Injury
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Swine
MH  - Thermodilution/*methods
MH  - Thorax
EDAT- 1999/04/08 00:00
MHDA- 1999/04/08 00:01
CRDT- 1999/04/08 00:00
PHST- 1999/04/08 00:00 [pubmed]
PHST- 1999/04/08 00:01 [medline]
PHST- 1999/04/08 00:00 [entrez]
AID - 10.1007/s001340050819 [doi]
PST - ppublish
SO  - Intensive Care Med. 1999 Feb;25(2):216-9. doi: 10.1007/s001340050819.