PMID- 10193955
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 85
IP  - 7
DP  - 1999 Apr 1
TI  - Factors affecting the risk of contralateral Wilms tumor development: a report 
      from the National Wilms Tumor Study Group.
PG  - 1616-25
AB  - BACKGROUND: Approximately 1% of children with unilateral Wilms tumor develop 
      contralateral disease. The authors assessed the demographic and histologic 
      features associated with metachronous bilateral Wilms tumor (BWT). METHODS: 
      Characteristics of all children registered on the first four National Wilms Tumor 
      Studies (NWTS) were recorded. The primary endpoint for evaluation was the first 
      appearance of Wilms tumor in the remaining kidney. The cumulative risk of 
      contralateral disease as a function of time since initial presentation was 
      calculated as 1 minus the Kaplan-Meier estimate of remaining free of 
      contralateral disease. A matched case control study was conducted to determine 
      whether the presence and type of nephrogenic rests (NRs) were associated with 
      metachronous BWT. RESULTS: Fifty-eight of 4669 registered children developed 
      metachronous BWT; 38 of 2445 females (expected, 30.2) versus 20 of 2224 males 
      (expected, 27.8) (P = 0.04) developed BWT. The cumulative incidence of 
      contralateral disease 6 years after initial diagnosis decreased from greater than 
      3% in the first NWTS to approximately 1.5% in the three subsequent studies (P = 
      0.08). Patients with NRs had a significantly increased risk of metachronous BWT. 
      This was particularly true for young children (20 of 206 age < 12 months compared 
      with 0 of 304 age > 12 months). Data from the matched case control study 
      confirmed the increased relative risk associated with young age and the presence 
      of NRs. CONCLUSIONS: Children younger than 12 months diagnosed with Wilms tumor 
      who also have NRs, in particular perilobar NRs, have a markedly increased risk of 
      developing contralateral disease and require frequent and regular surveillance 
      for several years. Surveillance is also recommended for those with NRs who are 
      diagnosed after the age of 12 months.
FAU - Coppes, M J
AU  - Coppes MJ
AD  - Alberta Children's Hospital and Tom Baker Cancer Centre, and Department of 
      Oncology, University of Calgary, Canada.
FAU - Arnold, M
AU  - Arnold M
FAU - Beckwith, J B
AU  - Beckwith JB
FAU - Ritchey, M L
AU  - Ritchey ML
FAU - D'Angio, G J
AU  - D'Angio GJ
FAU - Green, D M
AU  - Green DM
FAU - Breslow, N E
AU  - Breslow NE
LA  - eng
GR  - R01 CA054498/CA/NCI NIH HHS/United States
GR  - CA42326/CA/NCI NIH HHS/United States
GR  - CA54498/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Age Factors
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Infant
MH  - Kidney/abnormalities
MH  - Kidney Neoplasms/*pathology
MH  - Male
MH  - Neoplasms, Second Primary/*etiology
MH  - Time Factors
MH  - Wilms Tumor/*pathology
EDAT- 1999/04/08 02:03
MHDA- 2000/06/20 09:00
CRDT- 1999/04/08 02:03
PHST- 1999/04/08 02:03 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/04/08 02:03 [entrez]
AID - 10.1002/(SICI)1097-0142(19990401)85:7<1616::AID-CNCR26>3.0.CO;2-4 [pii]
AID - 10.1002/(sici)1097-0142(19990401)85:7<1616::aid-cncr26>3.0.co;2-4 [doi]
PST - ppublish
SO  - Cancer. 1999 Apr 1;85(7):1616-25. doi: 
      10.1002/(sici)1097-0142(19990401)85:7<1616::aid-cncr26>3.0.co;2-4.