PMID- 10195107
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20220309
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 1
IP  - 1
DP  - 1998 May
TI  - A role for BDNF in mechanosensation.
PG  - 42-6
AB  - Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory 
      neurons during development. Using electrophysiology in BDNF-deficient mice, we 
      show here that slowly adapting mechanoreceptors (SAM), but not other types of 
      cutaneous afferents, require BDNF in postnatal life for normal 
      mechanotransduction. Neurons lacking BDNF did not die, but instead showed a 
      profound and specific reduction in their mechanical sensitivity, which was 
      quantitatively the same in BDNF -/- and BDNF +/- animals. Postnatal treatment of 
      BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity 
      deficit. Therefore BDNF is important for regulating SAM mechanosensitivity, 
      independent of any survival-promoting function.
FAU - Carroll, P
AU  - Carroll P
AD  - Department of Neurobiochemistry, Max-Planck-Institute for Neurobiology, 
      Planegg-Martinsried, Germany.
FAU - Lewin, G R
AU  - Lewin GR
FAU - Koltzenburg, M
AU  - Koltzenburg M
FAU - Toyka, K V
AU  - Toyka KV
FAU - Thoenen, H
AU  - Thoenen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Recombinant Proteins)
SB  - IM
CIN - Nat Neurosci. 1998 May;1(1):5-6. PMID: 10195097
MH  - Adaptation, Physiological/physiology
MH  - Animals
MH  - Axons/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/pharmacology/*physiology
MH  - Cellular Senescence/physiology
MH  - Mechanoreceptors/drug effects/*physiology
MH  - Mice
MH  - Mice, Knockout/genetics
MH  - Myelin Sheath/physiology
MH  - Neurons, Afferent/physiology
MH  - Recombinant Proteins
MH  - Sensation/drug effects/*physiology
MH  - Skin/innervation
MH  - Time Factors
EDAT- 1999/04/09 00:00
MHDA- 1999/04/09 00:01
CRDT- 1999/04/09 00:00
PHST- 1999/04/09 00:00 [pubmed]
PHST- 1999/04/09 00:01 [medline]
PHST- 1999/04/09 00:00 [entrez]
AID - 10.1038/242 [doi]
PST - ppublish
SO  - Nat Neurosci. 1998 May;1(1):42-6. doi: 10.1038/242.