PMID- 10195229
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20081121
IS  - 1090-9508 (Print)
IS  - 1090-9508 (Linking)
VI  - 1
IP  - 1
DP  - 1997 Nov-Dec
TI  - Mother-to-child transmission of human T-cell lymphotropic virus type I associated 
      with prolonged breast-feeding.
PG  - 37-44
AB  - OBJECTIVES: We assessed the risk of transmitting human T-cell lymphotropic virus 
      type I (HTLV-I) through breast-feeding. STUDY DESIGN/METHODS: To assess the risk 
      of mother-to-child transmission of HTLV-I, 212 HTLV-I-seropositive women and 145 
      HTLV-I-seronegative women were enrolled in a prospective cohort study conducted 
      in Kingston, Jamaica. Their offspring were examined at regular intervals, and 
      HTLV-I serostatus was determined at each visit. RESULTS: Twenty-eight of the 181 
      children with at least one postnatal visit born to HTLV-I-seropositive women (and 
      none of the children born to HTLV-I-seronegative women) were persistently 
      seropositive and were considered HTLV-I infected (Kaplan-Meier estimated 
      cumulative incidence, 18%; 95% CI, 12%-24%). Among children observed for at least 
      24 months, 19 (32%) of 60 children breast fed for 12 months or longer were HTLV-I 
      seropositive, compared with only 8 (9%) of 86 children breast-fed for less than 
      12 months (relative risk, 3.4; 95% CI, 1.7-6.9). Compared with children weaned at 
      younger ages, transmission of HTLV-I was associated with continued breast-feeding 
      of children who were 12 to 18 months of age (relative hazard, 6.4; 95% CI, 
      2.1-180.2) and older than 18 months (relative hazard, 18.1; 95% CI, 1.4-29.5). 
      Transmission was also associated with higher maternal antibody titer (a possible 
      marker of virus load), prolonged duration of ruptured membranes during 
      childbirth, and lower maternal income. CONCLUSIONS: These results suggest that 
      limiting the duration of breast-feeding to less than 12 months for children born 
      to HTLV-I-seropositive mothers may significantly reduce mother-to-child 
      transmission of HTLV-I.
FAU - Wiktor, S Z
AU  - Wiktor SZ
AD  - Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20816, 
      USA.
FAU - Pate, E J
AU  - Pate EJ
FAU - Rosenberg, P S
AU  - Rosenberg PS
FAU - Barnett, M
AU  - Barnett M
FAU - Palmer, P
AU  - Palmer P
FAU - Medeiros, D
AU  - Medeiros D
FAU - Maloney, E M
AU  - Maloney EM
FAU - Blattner, W A
AU  - Blattner WA
LA  - eng
GR  - N01-CP-31006/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Hum Virol
JT  - Journal of human virology
JID - 9805755
SB  - IM
MH  - Adult
MH  - Breast Feeding/*adverse effects
MH  - Female
MH  - HTLV-I Infections/immunology/*transmission/virology
MH  - Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
EDAT- 1999/04/09 00:00
MHDA- 1999/04/09 00:01
CRDT- 1999/04/09 00:00
PHST- 1999/04/09 00:00 [pubmed]
PHST- 1999/04/09 00:01 [medline]
PHST- 1999/04/09 00:00 [entrez]
PST - ppublish
SO  - J Hum Virol. 1997 Nov-Dec;1(1):37-44.