PMID- 10195407
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20190831
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 246
IP  - 2
DP  - 1999 Feb
TI  - Paroxysmal kinesigenic choreoathetosis: a report of 26 patients.
PG  - 120-6
AB  - Paroxysmal kinesigenic choreoathetosis (PKC) is a neurological condition which 
      results in abnormal involuntary movements that are precipitated by sudden 
      movement. Because of its rarity, large case series of PKC have not been 
      published. We studied 26 patients with PKC, which represents the largest series 
      thus reported. We reviewed our cases with respect to attack characteristics, 
      aetiology, family history, and treatment response. Our population consisted of 23 
      men and 3 women. Seven patients had a family history of paroxysmal dyskinesia. 
      None of our patients had clear evidence of symptomatic PKC. Two-thirds of our 
      patients had attacks lasting between 30-60 s, and over one-half experienced one 
      to ten attacks per day. Attack distribution varied widely, and most experienced 
      pure dystonia rather than choreodystonic movements. Most patients responded very 
      well to anticonvulsant therapy. We also report the PET results from two of our 
      patients and Bereitschaftspotential abnormalities recorded from two others.
FAU - Houser, M K
AU  - Houser MK
AD  - Department of Clinical Neurophysiology, National Hospital for Neurology and 
      Neurosurgery, London, UK.
FAU - Soland, V L
AU  - Soland VL
FAU - Bhatia, K P
AU  - Bhatia KP
FAU - Quinn, N P
AU  - Quinn NP
FAU - Marsden, C D
AU  - Marsden CD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Anticonvulsants/therapeutic use
MH  - Athetosis/diagnosis/drug therapy/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Chorea/diagnosis/drug therapy/*epidemiology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Movement
MH  - Tomography, Emission-Computed
MH  - Tomography, X-Ray Computed
MH  - Volition
RF  - 38
EDAT- 1999/04/09 00:00
MHDA- 1999/04/09 00:01
CRDT- 1999/04/09 00:00
PHST- 1999/04/09 00:00 [pubmed]
PHST- 1999/04/09 00:01 [medline]
PHST- 1999/04/09 00:00 [entrez]
AID - 10.1007/s004150050318 [doi]
PST - ppublish
SO  - J Neurol. 1999 Feb;246(2):120-6. doi: 10.1007/s004150050318.