PMID- 10196460
OWN - NLM
STAT- MEDLINE
DCOM- 19990525
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 824
IP  - 2
DP  - 1999 Apr 10
TI  - Apoptotic cascade of neurons in the subcortical sensory relay nuclei following 
      the neonatal infraorbital nerve transection.
PG  - 284-90
AB  - A terminal transferase-mediated dUTP nick end labeling (TUNEL) method was 
      utilized for detection of neuronal death in the subcortical relay nuclei of the 
      trigeminosensory system following the infraorbital nerve transection in newborn 
      rats. At 18-24 h after injury, numerous TUNEL-positive profiles were found within 
      the ventroposteromedial thalamic nucleus (VPM) contralateral to the injury, 
      whereas the VPM on the ipsilateral side and of the age-matched normal control 
      contained only a few profiles per section. Electron microscopy revealed that the 
      TUNEL-positive profiles were apoptotic neurons. The ventral part of the 
      ipsilateral brainstem sensory trigeminal nuclear complex (the nucleus 
      principalis, and the subnuclei oralis and interpolaris) exhibited statistically 
      significant 65-70% increase in number of apoptotic neurons compared to the 
      contralateral side. Taken together with our previous study [T. Sugimoto, C. Xiao, 
      H. Ichikawa, Neonatal primary neuronal death induced by capsaicin and axotomy 
      involves an apoptotic mechanism, Brain Res. 807 (1998) 147-154], the present 
      results demonstrated a cascade of apoptosis in the primary, secondary and 
      tertiary order sensory neurons along the neuroaxis.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Sugimoto, T
AU  - Sugimoto T
AD  - Department of Oral Anatomy II, Okayama University Dental School, 2-5-1 
      Shikata-cho, Okayama 700-8525, Japan.
FAU - Xiao, C
AU  - Xiao C
FAU - Takeyama, A
AU  - Takeyama A
FAU - He, Y F
AU  - He YF
FAU - Takano-Yamamoto, T
AU  - Takano-Yamamoto T
FAU - Ichikawa, H
AU  - Ichikawa H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Apoptosis/*physiology
MH  - Female
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Neurons/*pathology
MH  - Orbit/*innervation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Trigeminal Nuclei/*pathology
EDAT- 1999/04/10 00:00
MHDA- 1999/04/10 00:01
CRDT- 1999/04/10 00:00
PHST- 1999/04/10 00:00 [pubmed]
PHST- 1999/04/10 00:01 [medline]
PHST- 1999/04/10 00:00 [entrez]
AID - S0006-8993(99)01237-8 [pii]
AID - 10.1016/s0006-8993(99)01237-8 [doi]
PST - ppublish
SO  - Brain Res. 1999 Apr 10;824(2):284-90. doi: 10.1016/s0006-8993(99)01237-8.