PMID- 10196583
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20171116
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 1
IP  - 8
DP  - 1998 Dec
TI  - Development of the quantal properties of evoked and spontaneous synaptic currents 
      at a brain synapse.
PG  - 675-82
AB  - In many studies of central synaptic transmission, the quantal properties of 
      miniature synaptic events do not match those derived from synaptic events evoked 
      by action potentials. Here we show that at mossy fiber-granule cell (MF-gc) 
      synapses of mature cerebellum, evoked excitatory postsynaptic currents (EPSCs) 
      are multiquantal, and their amplitudes vary in discrete steps, whereas miniature 
      (m)EPSCs are monoquantal or multiquantal with quantal parameters identical to 
      those of the EPSCs. In contrast, at immature MF-gc synapses, EPSCs are 
      multiquantal, but their amplitudes do not vary in discrete steps, whereas most 
      mEPSCs seem to be monoquantal with a broad and skewed amplitude distribution. The 
      results demonstrate that quantal variance decreases during synaptic development. 
      They also directly confirm the quantal hypothesis of neurotransmission at a 
      mature brain synapse.
FAU - Wall, M J
AU  - Wall MJ
AD  - Department of Pharmacology, University of Bristol, UK.
FAU - Usowicz, M M
AU  - Usowicz MM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Cellular Senescence/physiology
MH  - Evoked Potentials/physiology
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Male
MH  - Nerve Fibers/physiology
MH  - Neurons/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/*physiology
MH  - Synaptic Transmission/*physiology
EDAT- 1999/04/10 02:03
MHDA- 2001/03/23 10:01
CRDT- 1999/04/10 02:03
PHST- 1999/04/10 02:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/04/10 02:03 [entrez]
AID - 10.1038/3677 [doi]
PST - ppublish
SO  - Nat Neurosci. 1998 Dec;1(8):675-82. doi: 10.1038/3677.