PMID- 10197902
OWN - NLM
STAT- MEDLINE
DCOM- 19990716
LR  - 20190909
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 113
IP  - 1
DP  - 1999 Feb
TI  - Temporal discrimination learning in severe amnesic patients reveals an alteration 
      in the timing of eyeblink conditioned responses.
PG  - 10-8
AB  - This study investigated whether the hippocampal system plays a modulatory role in 
      the timing of conditioned responses (CRs) in eyeblink classical conditioning. 
      Seven bitemporal amnesic patients and 7 controls were randomly presented 2 tone 
      conditioned stimuli (CSs) that were individually paired with two different 
      interstimulus intervals (ISIs) in a delay conditioning task. It was found that 
      amnesic patients' CRs occurred significantly earlier than control participants' 
      CRs at the longer ISI. Amnesic patients also produced significantly more 
      nonadaptive CRs than did control participants, their level of acquisition was 
      less than that of control participants after equating for ISI, and they did not 
      show extinction with the longer ISI. These data suggest a role of the hippocampal 
      system in controlling the precise timing of conditioned eyeblink responses and in 
      acquiring and extinguishing responses within the context of a temporal 
      discrimination task.
FAU - McGlinchey-Berroth, R
AU  - McGlinchey-Berroth R
AD  - Geriatric Research Education and Clinical Center, Brockton/West Roxbury Veterans 
      Affairs Medical Center, West Roxbury, Massachusetts 02132, USA. rmcglin@bu.edu
FAU - Brawn, C
AU  - Brawn C
FAU - Disterhoft, J F
AU  - Disterhoft JF
LA  - eng
GR  - 00187/PHS HHS/United States
GR  - 1P50NS26985/NS/NINDS NIH HHS/United States
GR  - MH47340/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amnesia/*physiopathology
MH  - Blinking/*physiology
MH  - Brain Damage, Chronic/physiopathology
MH  - Brain Mapping
MH  - Conditioning, Classical/*physiology
MH  - Conditioning, Eyelid/*physiology
MH  - Discrimination Learning/*physiology
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Humans
MH  - Male
MH  - Mental Recall/physiology
MH  - Middle Aged
MH  - Reaction Time/physiology
MH  - Temporal Lobe/physiopathology
MH  - Time Perception/*physiology
EDAT- 1999/04/10 00:00
MHDA- 1999/04/10 00:01
CRDT- 1999/04/10 00:00
PHST- 1999/04/10 00:00 [pubmed]
PHST- 1999/04/10 00:01 [medline]
PHST- 1999/04/10 00:00 [entrez]
AID - 10.1037//0735-7044.113.1.10 [doi]
PST - ppublish
SO  - Behav Neurosci. 1999 Feb;113(1):10-8. doi: 10.1037//0735-7044.113.1.10.