PMID- 10198303
OWN - NLM
STAT- MEDLINE
DCOM- 19990518
LR  - 20190204
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 276
IP  - 4
DP  - 1999 Apr
TI  - Carbohydrate ingestion can completely suppress endogenous glucose production 
      during exercise.
PG  - E672-83
LID - 10.1152/ajpendo.1999.276.4.E672 [doi]
AB  - The purposes of this study were 1) to investigate the effect of carbohydrate 
      (CHO) ingestion on endogenous glucose production (EGP) during prolonged exercise, 
      2) to study whether glucose appearance in the circulation could be a limiting 
      factor for exogenous CHO oxidation, and 3) to investigate whether large CHO 
      feedings can reduce muscle glycogen oxidation during exercise. Six well-trained 
      subjects exercised three times for 120 min at 50% maximum workload while 
      ingesting water (FAST), a 4% glucose solution (LO-Glc), or a 22% glucose solution 
      (HI-Glc). A primed continuous intravenous [6, 6-2H2]glucose infusion was given, 
      and the ingested glucose was enriched with [U-13C]glucose. Glucose ingestion 
      significantly elevated CHO oxidation as well as the rates of appearance (Ra) and 
      disappearance. Ra glucose equaled Ra of glucose in gut (Ra gut) during HI-Glc, 
      whereas EGP was completely suppressed. During LO-Glc, EGP was partially 
      suppressed, whereas Ra gut provided most of the total glucose Ra. We conclude 
      that 1) high rates of CHO ingestion can completely block EGP, 2) Ra gut may be a 
      limiting factor for exogenous CHO oxidation, and 3) muscle glycogen oxidation was 
      not reduced by large glucose feedings.
FAU - Jeukendrup, A E
AU  - Jeukendrup AE
AD  - Department of Human Biology, Nutrition Research Centre, Maastricht University, 
      6200 MD Maastricht, The Netherlands. Jeukendrup@bham.ac.uk
FAU - Wagenmakers, A J
AU  - Wagenmakers AJ
FAU - Stegen, J H
AU  - Stegen JH
FAU - Gijsen, A P
AU  - Gijsen AP
FAU - Brouns, F
AU  - Brouns F
FAU - Saris, W H
AU  - Saris WH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 9005-79-2 (Glycogen)
RN  - AR09D82C7G (Deuterium)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Deuterium
MH  - *Dietary Carbohydrates
MH  - Exercise/*physiology
MH  - Fasting
MH  - Glucose/administration & dosage/*metabolism
MH  - Glycogen/*metabolism
MH  - Glycolysis
MH  - Humans
MH  - Infusions, Intravenous
MH  - Insulin/blood/metabolism
MH  - Insulin Secretion
MH  - Liver/metabolism
MH  - Metabolic Clearance Rate
MH  - Models, Biological
MH  - Muscle, Skeletal/*physiology
MH  - Oxygen Consumption
MH  - Physical Exertion/*physiology
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - 10.1152/ajpendo.1999.276.4.E672 [doi]
PST - ppublish
SO  - Am J Physiol. 1999 Apr;276(4):E672-83. doi: 10.1152/ajpendo.1999.276.4.E672.