PMID- 10198614
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 110
IP  - 1
DP  - 1999 Apr
TI  - Derivative chromosome 17 in a case of Burkitt lymphoma with 8;14 translocation.
PG  - 1-6
AB  - A complex chromosome rearrangement present in a B-cell line established from a 
      patient with Burkitt lymphoma was studied by using fluorescence in situ 
      hybridization (FISH) and immunocytochemistry techniques. The rearranged 
      chromosome (der17) was apparently composed of 17q, of a partially deleted 17p, 
      and of other material of chromosome 17p origin that was interspersed with regions 
      without any clear banding pattern. der(17) contained a functional ch17 centromere 
      and two additional centromeres of unknown origin that were inactive by all 
      evidence. By FISH analysis with a TP53 probe, a signal could be demonstrated on 
      the normal ch17, but not on the rearranged chromosome, a finding which indicates 
      that 17p deletion caused a concurrent loss of one of the two TP53 alleles. The 
      marker chromosome was previously observed in some of the malignant cells obtained 
      from the patient's peripheral blood. These observations therefore indicate that 
      cells with this specific rearrangement were generated in vivo and subsequently 
      selected. This rearrangement is likely to have conferred a selective growth 
      advantage to a subclone present in the original malignant cell population.
FAU - Ottaggio, L
AU  - Ottaggio L
AD  - CSTA-Mutagenesis Laboratory, National Institute for Cancer Research (IST), 
      Genova, Italy.
FAU - Moro, F
AU  - Moro F
FAU - Fronza, G
AU  - Fronza G
FAU - Roncella, S
AU  - Roncella S
FAU - Bozzo, S
AU  - Bozzo S
FAU - Campomenosi, P
AU  - Campomenosi P
FAU - Iga, A
AU  - Iga A
FAU - Ferranini, M
AU  - Ferranini M
FAU - Abbondandolo, A
AU  - Abbondandolo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Burkitt Lymphoma/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Genes, p53
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - S0165460898001733 [pii]
AID - 10.1016/s0165-4608(98)00173-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Apr;110(1):1-6. doi: 10.1016/s0165-4608(98)00173-3.