PMID- 10198617
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 110
IP  - 1
DP  - 1999 Apr
TI  - BCR/ABL translocation in adult acute lymphoblastic leukemia: a comparison of 
      conventional and interphase cytogenetic studies.
PG  - 19-22
AB  - Twenty-four adult Chinese patients with de novo acute lymphoblastic leukemia 
      (ALL) were studied for the BCR/ABL translocation using both conventional 
      cytogenetics and fluorescence in situ hybridization (FISH). Eight (33%) patients 
      had the translocation as shown by FISH and all were B-lineage ALL (8/19, 42%). 
      Conventional cytogenetics revealed a t(9;22)(q34;q11) in six of them, but was 
      either unsuccessful, or not done in the other two. Seven of the eight positive 
      cases (88%) showed a breakpoint at the minor breakpoint cluster region (m-BCR), 
      which was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). 
      To conclude, the frequency of BCR/ABL translocation in Chinese patients with de 
      novo ALL is comparable to patients in the Western hemisphere, in contrast to a 
      previous report. The predominance of m-BCR/ABL fusion among these Chinese 
      patients with BCR/ABL translocation is also similar to patients in the Western 
      population. Fluorescence in situ hybridization is a sensitive, specific and 
      relatively simple technique for demonstrating this important unfavorable 
      prognostic marker in ALL, even in a routine service laboratory setting.
FAU - So, C C
AU  - So CC
AD  - Department of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic 
      of China.
FAU - Wong, K F
AU  - Wong KF
FAU - Chung, J
AU  - Chung J
FAU - Kwong, Y L
AU  - Kwong YL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
RN  - EC 2.7.11.1 (BCR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-bcr)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Fusion Proteins, bcr-abl/genetics
MH  - *Genes, abl
MH  - Humans
MH  - Interphase
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Protein-Tyrosine Kinases
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-bcr
MH  - *Translocation, Genetic
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - S0165460898001848 [pii]
AID - 10.1016/s0165-4608(98)00184-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Apr;110(1):19-22. doi: 
      10.1016/s0165-4608(98)00184-8.