PMID- 10199758
OWN - NLM
STAT- MEDLINE
DCOM- 19990421
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 84
IP  - 4
DP  - 1999 Apr
TI  - Plasma concentrations of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF 
      receptors in patients with anorexia nervosa.
PG  - 1226-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with numerous immunological 
      and metabolic activities. To study the role of TNF-alpha on the pathophysiology 
      of anorexia nervosa and its complications, plasma concentrations of TNF-alpha, 2 
      soluble TNF receptors (sTNF-RI and sTNF-RII), and leptin were measured in 20 
      female patients with anorexia nervosa (AN) and 20 age-matched normal women (N). 
      Plasma TNF-alpha concentrations in AN were significantly higher than those in N 
      (4.1 +/- 0.6 pg/mL vs. 1.6 +/- 0.1 pg/mL; P < 0.01). Although no significant 
      difference was observed in plasma sTNF-RI concentrations between the two groups, 
      plasma sTNF-RII concentrations in AN were significantly higher than those in N 
      (2094.0 +/- 138.5 pg/mL vs. 1569.5 +/- 84.0 pg/mL; P < 0.01). Plasma 
      concentrations of TNF-alpha and sTNF-RII after treatment of 8 anorectic patients 
      were not different from those before treatment, although body fat mass and plasma 
      leptin concentrations significantly increased after treatment. Plasma TNF-alpha 
      concentrations were not related to body fat mass in anorectic patients. These 
      results suggest that the adipose tissue may not be the immediate source of 
      TNF-alpha in anorectic patients and that TNF-alpha may contribute to the 
      pathophysiology of immunological and metabolic abnormalities in anorexia nervosa.
FAU - Nakai, Y
AU  - Nakai Y
AD  - College of Medical Technology, Kyoto University, Japan. YN@itan.kyoto-u.ac.jp
FAU - Hamagaki, S
AU  - Hamagaki S
FAU - Takagi, R
AU  - Takagi R
FAU - Taniguchi, A
AU  - Taniguchi A
FAU - Kurimoto, F
AU  - Kurimoto F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Anorexia Nervosa/*blood
MH  - Antigens, CD/*blood
MH  - Female
MH  - Humans
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - 10.1210/jcem.84.4.5589 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1999 Apr;84(4):1226-8. doi: 10.1210/jcem.84.4.5589.