PMID- 10203020
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 53
IP  - 3
DP  - 1999 Mar
TI  - HLA-DR-DQ alleles and HLA-DP alleles are independently associated with 
      susceptibility to different stages of post-schistosomal hepatic fibrosis in the 
      Chinese population.
PG  - 269-74
AB  - Abstract: Evaluation of human leukocyte antigen (HLA) class I and class II genes 
      was performed on patients from China with Schistosomiasis japonica. Patients were 
      categorized as grade 0 (n=44), grade I (n=81), grade II (n=99), or grade III 
      (n=6) based on increasing severity of hepatic fibrosis due to repeated 
      Schistosoma japonicum infections. These results show that the 
      HLA-DRB1*1101-DQA1*0501-DQB1*0301 (Pc<0.02) and HLA-DRB1*1501-DRB5*0101 (Pc<0.02) 
      haplotypes are associated with protection and susceptibility to grade I fibrosis, 
      respectively, and that the HLA-DPA1*0103 -DPB1*0201 haplotype (Pc<0.02) is 
      associated with protection from both grade II and III severe fibrosis. There was 
      no association between HLA-B DNA haplotypes and the disease. These findings 
      indicate that the HLA-class II molecules play a role in preventing or promoting 
      fibrotic liver change after deposition with Schistosome eggs. Moreover, a 
      tendency was observed within the HLA class II genes for the HLA-DR-DQ alleles to 
      be associated with protection against early changes in liver fibrosis, whereas 
      HLA-DP alleles were associated with protection from the late phase of fibrosis or 
      severe hepatosplenic schistosomiasis.
FAU - Hirayama, K
AU  - Hirayama K
AD  - Department of Medical Zoology, Saitama Medical School, Moroyama, Japan. 
      hiraken@saitama-med.ac.jp
FAU - Chen, H
AU  - Chen H
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Yin, T
AU  - Yin T
FAU - Gu, X
AU  - Gu X
FAU - Liu, J
AU  - Liu J
FAU - Zhang, S
AU  - Zhang S
FAU - Yuan, H
AU  - Yuan H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Alleles
MH  - China
MH  - Genetic Predisposition to Disease
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - Liver Cirrhosis/*complications/diagnostic imaging/*genetics
MH  - Schistosomiasis japonica/*complications/diagnostic imaging/*genetics
MH  - Ultrasonography
EDAT- 1999/04/15 00:00
MHDA- 1999/04/15 00:01
CRDT- 1999/04/15 00:00
PHST- 1999/04/15 00:00 [pubmed]
PHST- 1999/04/15 00:01 [medline]
PHST- 1999/04/15 00:00 [entrez]
AID - 10.1034/j.1399-0039.1999.530307.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1999 Mar;53(3):269-74. doi: 10.1034/j.1399-0039.1999.530307.x.