PMID- 10203751
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20191103
IS  - 1357-4310 (Print)
IS  - 1357-4310 (Linking)
VI  - 5
IP  - 4
DP  - 1999 Apr
TI  - HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives 
      an old story.
PG  - 178-86
AB  - Human leukocyte antigen (HLA) class I molecule downregulation occurs frequently 
      in many cancers, and this abnormality might adversely affect the clinical course 
      of cancer and the outcome of T-cell-based immunotherapy. Mutations in the HLA 
      class I genes themselves, abnormalities in their regulation and/or defects in HLA 
      class I-dependent antigen processing can underlie HLA class I downregulation. 
      These mutations modulate the susceptibility of tumor cells to in vitro lysis by 
      cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Immune selection of 
      CTL- and NK-cell-resistant tumor cells might explain the rapid progression and 
      poor prognosis of cancers that exhibit HLA class I downregulation. These findings 
      provide compelling evidence that HLA class I downregulation represents a 
      significant challenge for the successful application of T-cell-based 
      immunotherapy of cancer.
FAU - Hicklin, D J
AU  - Hicklin DJ
AD  - Dept of Immunology, ImClone Systems Incorporated, New York, NY 10014, USA.
FAU - Marincola, F M
AU  - Marincola FM
FAU - Ferrone, S
AU  - Ferrone S
LA  - eng
GR  - CA51814/CA/NCI NIH HHS/United States
GR  - CA67988/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Mol Med Today
JT  - Molecular medicine today
JID - 9508560
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Down-Regulation
MH  - *Gene Expression Regulation, Neoplastic
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunotherapy
MH  - Neoplasms/genetics/*immunology/therapy
MH  - T-Lymphocytes/*immunology
RF  - 50
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S1357-4310(99)01451-3 [pii]
AID - 10.1016/s1357-4310(99)01451-3 [doi]
PST - ppublish
SO  - Mol Med Today. 1999 Apr;5(4):178-86. doi: 10.1016/s1357-4310(99)01451-3.