PMID- 10204050
OWN - NLM
STAT- MEDLINE
DCOM- 19990426
LR  - 20151119
IS  - 1078-5884 (Print)
IS  - 1078-5884 (Linking)
VI  - 17
IP  - 4
DP  - 1999 Apr
TI  - Cytokine and fibrinogen response in patients undergoing open abdominal aortic 
      aneurysm surgery.
PG  - 294-300
AB  - OBJECTIVES: To assess whether open abdominal aortic aneurysm (AAA) surgery 
      influences cytokines and fibrinogen. METHODS: Twenty-three consecutive patients 
      operated on for AAA were compared to 11 operated controls and 20 age-matched 
      controls. Cubital blood was sampled pre-, intra- and postoperatively and femoral 
      blood also sampled intraoperatively. RESULTS: Preoperatively, interleukin (Il)-6 
      was elevated in AAA patients. During aortic clamping, Il-6, Il-10 and monocyte 
      chemoattractant protein-1 (MCP-1) increased significantly (p < 0.001, p < 0.01 
      and p < 0.05 respectively) while soluble interleukin-2 receptor (sIl-2R) and 
      fibrinogen decreased significantly (p < 0.001 for both). After aortic declamping, 
      Il-6, Il-10 and MCP-1 had further significant increases compared with levels 
      during aortic clamping while sIl-2R had a further non-significant and fibrinogen 
      a significant decrease (p < 0.05 in cubital and p < 0.001 in femoral blood). One 
      week postoperatively Il-6, Il-10 and MCP-1 had all decreased but were still 
      significantly elevated compared with baseline values while sIl-2R and fibrinogen 
      showed an increase in comparison with baseline (p < 0.001 for both). 
      Intraoperative levels of Il-6 and Il-10 showed a significant co-variation with 
      the magnitude of operative trauma. CONCLUSIONS: These data indicate that open AAA 
      surgery induces a profound inflammatory and coagulative response which persists 
      at one week postoperatively.
FAU - Holmberg, A
AU  - Holmberg A
AD  - Department of Surgery, University Hospital Uppsala, Sweden.
FAU - Bergqvist, D
AU  - Bergqvist D
FAU - Westman, B
AU  - Westman B
FAU - Siegbahn, A
AU  - Siegbahn A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/immunology/*surgery
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Fibrinogen/*metabolism
MH  - Humans
MH  - Intraoperative Complications/*diagnosis/immunology
MH  - Male
MH  - Middle Aged
MH  - Reperfusion Injury/blood/diagnosis
MH  - Systemic Inflammatory Response Syndrome/*diagnosis/immunology
EDAT- 1999/04/16 00:00
MHDA- 1999/04/16 00:01
CRDT- 1999/04/16 00:00
PHST- 1999/04/16 00:00 [pubmed]
PHST- 1999/04/16 00:01 [medline]
PHST- 1999/04/16 00:00 [entrez]
AID - S1078-5884(98)90767-5 [pii]
AID - 10.1053/ejvs.1998.0767 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 1999 Apr;17(4):294-300. doi: 10.1053/ejvs.1998.0767.