PMID- 10204541
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20131121
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 2
IP  - 4
DP  - 1999 Apr
TI  - Presynaptic depolarization facilitates neurotrophin-induced synaptic 
      potentiation.
PG  - 346-51
AB  - Neurotrophins have been proposed to participate in activity-dependent 
      modifications of neuronal connectivity and synaptic efficacy. Preferential 
      strengthening of active inputs requires restriction of putative 
      neurotrophin-mediated synaptic potentiation to active synapses. Here we report 
      that potentiation of synaptic efficacy by brain-derived neurotrophic factor 
      (BDNF) is greatly facilitated by presynaptic depolarization at developing 
      neuromuscular synapses. Brief depolarization in the presence of low-level BDNF 
      results in a marked potentiation of both evoked and spontaneous synaptic 
      transmission, whereas exposure to either BDNF or depolarization alone is without 
      effect. This potentiation depends on the relative timing of depolarization and 
      reflects an enhancement of transmitter secretion from the presynaptic neuron. 
      Thus synapses made by active inputs may be selectively strengthened by secreted 
      neurotrophins as part of activity-dependent refinement of developing connections 
      or of mature synapses.
FAU - Boulanger, L M
AU  - Boulanger LM
AD  - Department of Biology, University of California at San Diego, La Jolla 
      92093-0357, USA.
FAU - Poo, M M
AU  - Poo MM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
EIN - Nat Neurosci. 2008 Feb;11(2):238. Boulanger, L [corrected to Boulanger, L M]
MH  - Action Potentials
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Calcium/physiology
MH  - Cells, Cultured
MH  - Evoked Potentials/drug effects
MH  - Membrane Potentials/drug effects
MH  - Neuromuscular Junction/*drug effects/physiology
MH  - Patch-Clamp Techniques
MH  - Potassium/pharmacology
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Xenopus laevis
EDAT- 1999/04/16 02:03
MHDA- 2001/03/23 10:01
CRDT- 1999/04/16 02:03
PHST- 1999/04/16 02:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/04/16 02:03 [entrez]
AID - 10.1038/7258 [doi]
PST - ppublish
SO  - Nat Neurosci. 1999 Apr;2(4):346-51. doi: 10.1038/7258.