PMID- 10205782
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190831
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 113
IP  - 2
DP  - 1999 Feb
TI  - [Metabotropic glutamate receptor: its ligands and function in the olfactory 
      system].
PG  - 73-83
AB  - The metabotropic glutamate receptors (mGluRs) consist of at least eight different 
      subtypes. However, the lack of specific ligands for this class of receptors 
      limited the characterization of their roles. In this study, a series of glutamate 
      derivatives was systematically tested for agonist and antagonist activities for 
      the mGluR subtypes, individually expressed in cell lines. Among various compounds 
      tested, (2S, 1'R, 2'R, 3'R)-2-(2,3-dicarboxycyclopropyl) glycine (DCG-IV) was 
      found to be an effective agonist for mGluR2 and 
      alpha-methyl-4-carboxyphenylglycine (alpha M4CPG) was found to be an antagonist 
      for both mGluR1 and mGluR2. Using DCG-IV, I showed that mGluR2 mediates 
      presynaptic inhibition of GABA release from granule cells at the dendrodendritic 
      synapse of the accessory olfactory bulb (AOB). This mechanism was considered to 
      relieve a mitral cell from GABAergic inhibition and, furthermore, to be involved 
      in lateral inhibition of surrounding mitral cells and thus enhancing the 
      signal/noise ratio of olfactory sensation. I also show that an activation of 
      mGluR2 in AOB by infusion of DCG-IV induces olfactory memory, which can mimic the 
      pregnancy block phenomenon of female mice. This is the first report of a role of 
      specific subtype of mGluR in the central nervous system.
FAU - Hayashi, Y
AU  - Hayashi Y
AD  - Cold Spring Harbor Laboratory, NY 11724, USA.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Ligands)
RN  - 0 (Receptors, Metabotropic Glutamate)
SB  - IM
MH  - Animals
MH  - Female
MH  - Ligands
MH  - Mice
MH  - Olfactory Bulb/physiology
MH  - Pregnancy/physiology
MH  - Receptors, Metabotropic Glutamate/antagonists & inhibitors/*physiology
MH  - Smell/*physiology
MH  - Synaptic Transmission/physiology
RF  - 38
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1254/fpj.113.73 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 1999 Feb;113(2):73-83. doi: 10.1254/fpj.113.73.