PMID- 10206227
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20190905
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 88
IP  - 2
DP  - 1999 Apr 16
TI  - Dopamine D1 receptor gene polymorphism and schizophrenia in Japan.
PG  - 116-9
AB  - We studied the relationship between schizophrenia and the DdeI polymorphism in 
      the 5' untranslated region (5'UTR) of the dopamine D1 receptor (DRD1) gene. This 
      polymorphism is an A (A1 allele) to G (A2 allele) transition in the 5' UTR of 
      exon 2 at bp -48 (A-48G). One hundred forty-eight schizophrenics and 148 control 
      subjects were investigated. No significant differences in genotypic counts and 
      allele frequencies between schizophrenics and controls were found. Although a 
      significant difference between the patients classified as disorganized type and 
      the controls was discovered both in genotypic counts and allele frequencies, 
      neither association proved significant when a Bonferroni correction was used. 
      Moreover, there were no differences in scores of main symptoms of schizophrenia 
      based on the Manchester Scale between patients with A1/A1 genotype and those with 
      A1/A2 genotype. These findings suggest that this gene may not be involved in the 
      pathogenesis of schizophrenia.
FAU - Kojima, H
AU  - Kojima H
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Ohmori, O
AU  - Ohmori O
FAU - Shinkai, T
AU  - Shinkai T
FAU - Terao, T
AU  - Terao T
FAU - Suzuki, T
AU  - Suzuki T
FAU - Abe, K
AU  - Abe K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (Receptors, Dopamine D1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptors, Dopamine D1/*genetics
MH  - Schizophrenia/*genetics
EDAT- 1999/04/17 02:15
MHDA- 2000/06/20 09:00
CRDT- 1999/04/17 02:15
PHST- 1999/04/17 02:15 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/04/17 02:15 [entrez]
AID - 10.1002/(SICI)1096-8628(19990416)88:2<116::AID-AJMG3>3.0.CO;2-Y [pii]
AID - 10.1002/(sici)1096-8628(19990416)88:2<116::aid-ajmg3>3.0.co;2-y [doi]
PST - ppublish
SO  - Am J Med Genet. 1999 Apr 16;88(2):116-9. doi: 
      10.1002/(sici)1096-8628(19990416)88:2<116::aid-ajmg3>3.0.co;2-y.