PMID- 10206442
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 48
IP  - 4
DP  - 1999 Apr
TI  - Altered purine and glycogen metabolism in skeletal muscle during exercise in 
      patients with heart failure.
PG  - 484-8
AB  - Plasma levels of ammonia and hypoxanthine (HX) can be indices of purine 
      nucleotide degradation. The present study determined if patients with heart 
      failure (HF) have altered exercise plasma ammonia and HX levels relative to the 
      peak work rate performed. Blood lactate, plasma ammonia, and plasma HX levels 
      were measured in 59 patients with HF (New York Heart Association [NYHA] classes 
      I:20, II:21, and III:18) and 21 controls at rest and after a maximal 
      cardiopulmonary exercise test. The peak work rate (normal and NYHA I, II, and 
      III, 163+/-11, 152+/-9, 94+/-5, and 69+/-5 W) and peak oxygen uptake ([VO2] 
      32.3+/-1.7, 25.1+/-0.9, 18.6+/-0.5, and 14.1+/-0.6 mL/min/kg) decreased as the 
      NYHA functional class increased. The increment from rest to peak exercise (delta) 
      for lactate ([(delta)lactate] 6.1+/-0.3, 4.8+/-0.4, 4.6+/-0.3, and 2.9+/-0.3 
      mmol/L), (delta)ammonia (132+/-14, 119+/-20, 94+/-13, and 32+/-6 microg/dL), and 
      (delta)HX (33.5+/-3.4, 24.9+/-4.7, 20.6+/-3.0, and 9.9+/-1.2 micromol/L) was 
      progressively smaller as HF worsened. The ratio for (delta)lactate to peak work 
      rate (0.037+/-0.003, 0.032+/-0.004, 0.049+/-0.003, and 0.042+/-0.005) was higher 
      in classes II to III HF, while the ratio for (delta)ammonia to peak work rate 
      (0.81+/-0.14, 0.78+/-0.16, 0.99+/-0.11, and 0.47+/-0.11) was significantly lower 
      in class III HF. In summary, patients with HF exhibited a smaller ammonia 
      response with a higher lactate response to exercise when normalized with the peak 
      work rate. These results suggest there may be an altered purine and glycogen 
      metabolism during exercise in skeletal muscle in patients with HF.
FAU - Kinugawa, T
AU  - Kinugawa T
AD  - First Department of Internal Medicine, Tottori University School of Medicine, 
      Yonago, Japan.
FAU - Ogino, K
AU  - Ogino K
FAU - Kato, M
AU  - Kato M
FAU - Kato, T
AU  - Kato T
FAU - Osaki, S
AU  - Osaki S
FAU - Endo, A
AU  - Endo A
FAU - Igawa, O
AU  - Igawa O
FAU - Hisatome, I
AU  - Hisatome I
FAU - Shigemasa, C
AU  - Shigemasa C
FAU - Holmes, E W
AU  - Holmes EW
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Purines)
RN  - 2TN51YD919 (Hypoxanthine)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7664-41-7 (Ammonia)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Ammonia/blood
MH  - Blood Pressure/physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Glycogen/*metabolism
MH  - Heart Failure/*metabolism/physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Hypoxanthine/blood
MH  - Lactic Acid/blood
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*metabolism
MH  - Purines/*metabolism
MH  - Respiratory Mechanics/physiology
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - S0026-0495(99)90108-7 [pii]
AID - 10.1016/s0026-0495(99)90108-7 [doi]
PST - ppublish
SO  - Metabolism. 1999 Apr;48(4):484-8. doi: 10.1016/s0026-0495(99)90108-7.