PMID- 10206454
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20190915
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 21
IP  - 2
DP  - 1999 Mar-Apr
TI  - Chromosomal rearrangements in childhood acute myeloid leukemia and 
      myelodysplastic syndromes.
PG  - 91-102
AB  - Recurrent chromosomal abnormalities present in the malignant cells of children 
      with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) often 
      correlate closely with specific clinical and biologic characteristics of the 
      disease. Certain unique cytogenetic rearrangements are associated with distinct 
      morphologic leukemic subtypes. These rearrangements should be detectable in most 
      children with AML and MDS with the use of complementary molecular techniques such 
      as fluorescence in situ hybridization (FISH), Southern blotting, and polymerase 
      chain reaction. Apart from the diagnostic assessment, cytogenetic findings 
      sometimes predict clinical outcome and thus also serve as prognostic parameters, 
      which may affect the therapeutic decision. Alternative classifications of AML 
      that take into account the genetic information are being proposed. Cytogenetic 
      and molecular analyses may allow clinicians to more appropriately direct types of 
      treatment. Abnormal fusion transcripts and chimeric proteins derived from 
      karyotypic abnormalities now are being also targeted by novel therapeutic 
      approaches.
FAU - Martinez-Climent, J A
AU  - Martinez-Climent JA
AD  - Department of Hematology and Oncology, Hospital Clinico Universitario, University 
      of Valencia, Spain.
FAU - Garcia-Conde, J
AU  - Garcia-Conde J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Biomarkers, Tumor/genetics
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human/genetics/ultrastructure
MH  - Female
MH  - Humans
MH  - Infant
MH  - Leukemia, Myeloid/classification/*genetics/mortality
MH  - Male
MH  - Myelodysplastic Syndromes/*genetics/mortality
MH  - Neoplasms, Second Primary/genetics/mortality
MH  - Oncogene Proteins, Fusion/genetics
MH  - Oncogenes
MH  - Patient Care Planning
MH  - Polyploidy
MH  - Prognosis
MH  - Translocation, Genetic
RF  - 182
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1097/00043426-199903000-00004 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 1999 Mar-Apr;21(2):91-102. doi: 
      10.1097/00043426-199903000-00004.