PMID- 10206458
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20190915
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 21
IP  - 2
DP  - 1999 Mar-Apr
TI  - Hemolytic uremic syndrome in children: platelet aggregation and membrane 
      glycoproteins.
PG  - 123-8
AB  - PURPOSE: Several mechanisms have been proposed to explain the fibrin-platelet 
      thrombosis at the microcirculation level in the different clinical conditions of 
      hemolytic uremic syndrome (HUS). The relationships between platelet structure and 
      function during the first 4 weeks of evolution of the disease were studied to 
      understand the mechanism of platelet alteration. PATIENTS AND METHODS: 
      Coagulation parameters, platelet counts, and aggregation were studied in 49 
      children, and membrane glycoproteins (GPs) in 20 of the 49 children (mean age, 17 
      months) with HUS (Group 2) were studied during the first 4 weeks of evolution of 
      the disease. RESULTS: No disseminated intravascular coagulation was found in 
      patients with recurrent or persistent thrombocytopenia. Platelet aggregation was 
      sequentially performed during the first weeks of evolution. All patients had a 
      functional decrease in the acute period of HUS. Platelet GPs GPIb, GPIIbIIIa, 
      GPIIb, and GPIIIa were evaluated. GPIIbIIIa complex presented low level and never 
      reached normal values during the first 4 weeks of disease. CONCLUSIONS: Platelet 
      alterations are probably caused by multiple mechanisms: "exhausted" platelets, 
      structural membrane alterations caused by arginine-glycine-aspartic peptide 
      blockade, or diminished or nonfunctional membrane GPIb and GPIIbIIIa complexes.
FAU - Sassetti, B
AU  - Sassetti B
AD  - Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, 
      Universidad de Buenos Aires, Argentina.
FAU - Vizcarguenaga, M I
AU  - Vizcarguenaga MI
FAU - Zanaro, N L
AU  - Zanaro NL
FAU - Silva, M V
AU  - Silva MV
FAU - Kordich, L
AU  - Kordich L
FAU - Florentini, L
AU  - Florentini L
FAU - Diaz, M
AU  - Diaz M
FAU - Vitacco, M
AU  - Vitacco M
FAU - Sanchez Avalos, J C
AU  - Sanchez Avalos JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Bacterial Toxins)
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Blood Proteins)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Shiga Toxin 1)
RN  - 0 (Trihexosylceramides)
RN  - 71965-57-6 (globotriaosylceramide)
SB  - IM
MH  - Bacterial Toxins/adverse effects
MH  - Blood Coagulation Factors/analysis
MH  - Blood Proteins/analysis
MH  - Child, Preschool
MH  - Diarrhea, Infantile/complications
MH  - Dysentery, Bacillary/complications
MH  - Endothelium, Vascular/pathology
MH  - Escherichia coli Infections/complications
MH  - Female
MH  - Hemolytic-Uremic Syndrome/*blood/physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Microcirculation
MH  - *Platelet Aggregation
MH  - Platelet Count
MH  - Platelet Membrane Glycoproteins/*deficiency
MH  - Shiga Toxin 1
MH  - Spleen/physiopathology
MH  - Thrombophilia/etiology
MH  - Trihexosylceramides/metabolism
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1097/00043426-199903000-00008 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 1999 Mar-Apr;21(2):123-8. doi: 
      10.1097/00043426-199903000-00008.