PMID- 10207955
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20191103
IS  - 0105-0397 (Print)
IS  - 0105-0397 (Linking)
VI  - 28
IP  - 1
DP  - 1999
TI  - Prevalence of hereditary hearing impairment in adults.
PG  - 39-46
AB  - This contribution, part of an EU-Concerted Action on the genetics of hearing 
      impairment (H.E.A.R.), describes the preliminary estimated prevalence of 
      hereditary hearing impairment based on retrospective data from a clinical series. 
      Of 27,692 subjects examined in the period 1987-91, we sampled 1265 suffering from 
      unilateral or bilateral hereditary hearing impairment, which is roughly 5% of 
      those examined (n = 384 (31%) male; n = 881 (69%) female). Median age of the 
      subjects is 70 years (range 22-98). Subdividing them into 10-year birth cohorts 
      and applying the local annual population statistics, the prevalence of an overall 
      age-related hereditary hearing impairment was roughly estimated to be 3.2/1000, 
      reflecting prevalences as a function of age from 0.8 to 9.4/1000--prevalence in 
      females being significantly more than in males (4.1/1000 and 2.1/1000, 
      respectively). Overall, a moderate hearing impairment of median 51 dB in the 
      better hearing ear was found, averaged across 0.5-4 kHz, this being fairly 
      constant up to the age of 60, when a significant reduction in hearing sensitivity 
      developed. No significant differences are present as a function of gender, except 
      for the birth cohorts 1910-19 and 1920-29. The most frequent type of hereditary 
      hearing impairment in this sample is otosclerosis, comprising 2% of the total 
      clinical series with a rough population prevalence estimate of 1.4/1000. It is 
      concluded that the established database may be of importance in the aggregation 
      of very rare diseases, and for providing the inspiration for future prospective 
      population studies, resulting in knowledge on the epidemiology of hereditary 
      hearing impairment in adults.
FAU - Sakihara, Y
AU  - Sakihara Y
AD  - Department of Audiology, Bispebjerg Hospital H:S, DK Copenhagen NV, Denmark.
FAU - Christensen, B
AU  - Christensen B
FAU - Parving, A
AU  - Parving A
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Scand Audiol
JT  - Scandinavian audiology
JID - 0342230
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Audiometry, Pure-Tone/methods
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Female
MH  - Hearing Loss, Sensorineural/diagnosis/epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - 10.1080/010503999424897 [doi]
PST - ppublish
SO  - Scand Audiol. 1999;28(1):39-46. doi: 10.1080/010503999424897.