PMID- 10208497
OWN - NLM
STAT- MEDLINE
DCOM- 19990528
LR  - 20220227
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 143
IP  - 1
DP  - 1999 Mar
TI  - Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein 
      E-deficient mice.
PG  - 205-11
AB  - The accumulation of circulating monocytes in the arterial wall is an early event 
      in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) 
      has been implicated as the primary source of monocyte chemoattractant functioning 
      in these early stages of atherogenesis. To determine whether the receptor for 
      MCP-1, CC chemokine receptor CCR2, plays a role in atherogenesis, CCR2-deficient 
      animals were crossed with mice lacking apo E, a well characterized model of 
      atherosclerosis. While lipid levels were unchanged, the double knockout mice 
      exhibited a 3-fold reduction in mean aortic lesion area compared to apo 
      E-deficient control mice. Furthermore, the lesions in the double mutants were 
      less advanced, consisting primarily of foam cell deposits and fatty streaks 
      located on or directly adjacent to the aortic valve attachment sites. These 
      studies directly demonstrate that the MCP-1 receptor, CCR2, plays an important 
      role in atherogenesis.
FAU - Dawson, T C
AU  - Dawson TC
AD  - Department of Pathology and Laboratory Medicine, University of North Carolina 
      Medical School, Chapel Hill 27599-7525, USA. tcdawson@med.unc.edu
FAU - Kuziel, W A
AU  - Kuziel WA
FAU - Osahar, T A
AU  - Osahar TA
FAU - Maeda, N
AU  - Maeda N
LA  - eng
GR  - HL42630/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Apolipoproteins E)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - Aorta/pathology
MH  - Apolipoproteins E/*deficiency/genetics
MH  - Arteriosclerosis/metabolism/*pathology
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - Lipids/blood
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/genetics/*metabolism
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - S0021-9150(98)00318-9 [pii]
AID - 10.1016/s0021-9150(98)00318-9 [doi]
PST - ppublish
SO  - Atherosclerosis. 1999 Mar;143(1):205-11. doi: 10.1016/s0021-9150(98)00318-9.