PMID- 10208950
OWN - NLM
STAT- MEDLINE
DCOM- 19991013
LR  - 20190501
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Print)
IS  - 0003-9888 (Linking)
VI  - 80
IP  - 5
DP  - 1999 May
TI  - Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency.
PG  - 443-7
AB  - BACKGROUND: Growth hormone insufficiency (GHI) is diagnosed conventionally by 
      short stature and slow growth, and is confirmed by diminished peak GH response to 
      a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 
      3 (IGFBP-3) have previously been considered individually OBJECTIVE: To test the 
      hypothesis that the combined analysis of IGF-I and IGFBP-3 could act as a 
      surrogate marker for the diagnosis of GHI. DESIGN: Reference ranges for IGF-I and 
      IGFBP-3 were calculated using 521 normal individuals. A retrospective analysis 
      was performed on 318 children referred for investigation of short stature. 
      RESULTS: No significant difference was found between either the IGF-I or IGFBP-3 
      standard deviation scores (SDSs) in children with and without GHI. If the 
      requirement were for both tests to be positive (< -2 SDS) for a diagnosis of GHI, 
      then 99% of children without GHI would be correctly identified; however, the 
      sensitivity of the test was only 15%. CONCLUSIONS: Neither IGF-I nor IGFBP-3 
      alone is a marker for GHI. In addition, they cannot be used as an effective 
      screening test in combination.
FAU - Mitchell, H
AU  - Mitchell H
AD  - London Centre for Paediatric Endocrinology, Great Ormond Street and The Middlesex 
      Hospitals, London W1H 8AA, UK.
FAU - Dattani, M T
AU  - Dattani MT
FAU - Nanduri, V
AU  - Nanduri V
FAU - Hindmarsh, P C
AU  - Hindmarsh PC
FAU - Preece, M A
AU  - Preece MA
FAU - Brook, C G
AU  - Brook CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
CIN - Arch Dis Child. 2000 Mar;82(3):270. PMID: 10722411
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Height
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Growth Disorders/*diagnosis
MH  - Human Growth Hormone/*deficiency
MH  - Humans
MH  - Infant
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
PMC - PMC1717917
EDAT- 1999/04/20 02:04
MHDA- 2000/04/25 09:00
PMCR- 2002/05/01
CRDT- 1999/04/20 02:04
PHST- 1999/04/20 02:04 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 1999/04/20 02:04 [entrez]
PHST- 2002/05/01 00:00 [pmc-release]
AID - 10.1136/adc.80.5.443 [doi]
PST - ppublish
SO  - Arch Dis Child. 1999 May;80(5):443-7. doi: 10.1136/adc.80.5.443.