PMID- 10208980
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190513
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 60
IP  - 5
DP  - 1999 May
TI  - Tissue-specific expression of messenger ribonucleic acids for insulin-like growth 
      factors and insulin-like growth factor-binding proteins during perinatal 
      development of the rat uterus.
PG  - 1172-82
AB  - Insulin-like growth factor (IGF)-I and IGF-II play a number of important roles in 
      growth and differentiation, and IGF-binding proteins (IGFBPs) modulate IGF 
      biological activity. IGF-I has been shown previously to be essential for normal 
      uterine development. Therefore, we used in situ hybridization assays to 
      characterize the unique tissue- and developmental stage-specific pattern of 
      expression for each IGF and IGFBP gene in the rat uterus during perinatal 
      development (gestational day [GD]-20 to postnatal day [PND]-24). IGF-I and 
      IGFBP-1 mRNAs were expressed in all uterine tissues throughout this period. 
      IGFBP-3 mRNA was not detectable at GD-20 but became detectable beginning at 
      PND-5, and the signal intensity appeared to increase during stromal and muscle 
      development. IGFBP-4 mRNA was abundant throughout perinatal development in the 
      myometrium and in the stroma, particularly near the luminal epithelium. IGFBP-5 
      mRNA was abundantly expressed in myometrium throughout perinatal development. 
      IGFBP-6 mRNA was detected throughout perinatal development in both the stroma and 
      myometrium in a diffuse expression pattern. IGF-II and IGFBP-2 mRNAs were not 
      detected in perinatal uteri. Our results suggest that coordinated temporal and 
      spatial expression of IGF-I and its binding proteins (IGFBP-1,-3,-4,-5, and -6) 
      could play important roles in perinatal rodent uterine development.
FAU - Gu, Y
AU  - Gu Y
AD  - Division of Genetic and Reproductive Toxicology, National Center for 
      Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, 
      USA.
FAU - Branham, W S
AU  - Branham WS
FAU - Sheehan, D M
AU  - Sheehan DM
FAU - Webb, P J
AU  - Webb PJ
FAU - Moland, C L
AU  - Moland CL
FAU - Streck, R D
AU  - Streck RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (RNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Somatomedins)
SB  - IM
MH  - Animals
MH  - Female
MH  - In Situ Hybridization
MH  - Insulin-Like Growth Factor Binding Proteins/*biosynthesis
MH  - Pregnancy
MH  - RNA Probes
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Somatomedins/*biosynthesis
MH  - Uterus/*embryology/*metabolism
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - 10.1095/biolreprod60.5.1172 [doi]
PST - ppublish
SO  - Biol Reprod. 1999 May;60(5):1172-82. doi: 10.1095/biolreprod60.5.1172.