PMID- 10211108
OWN - NLM
STAT- MEDLINE
DCOM- 19990426
LR  - 20041117
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 186
IP  - 3
DP  - 1998 Nov
TI  - The impact of FISH on our understanding of testicular tumour development.
PG  - 225-6
AB  - The fusion of techniques of classical cytogenetics and molecular biology has led 
      to the establishment of the fluorescence in situ hybridization (FISH) technique. 
      This method, allowing detailed chromosomal investigations in metaphase spreads as 
      well as in interphase nuclei, has enabled pathologists to detect molecular 
      changes in precancerous lesions such as carcinoma in situ of the testis. In 
      particular, its application to paraffin material has allowed the correlation of 
      chromosomal aberrations with morphological and immunohistochemical 
      characteristics. Thus, recurrent chromosomal aberrations found in invasive 
      testicular tumours, such as the occurrence of an isochromosome i(12p), are 
      already present in preinvasive stages, indicating an early event in 
      carcinogenesis. Recent work, published in this issue, presents the diagnostic 
      impact of these investigations.
FAU - Ensinger, C
AU  - Ensinger C
FAU - Mikuz, G
AU  - Mikuz G
LA  - eng
PT  - Editorial
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
SB  - IM
MH  - Carcinoma in Situ/genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Isochromosomes
MH  - Male
MH  - Precancerous Conditions/genetics
MH  - Testicular Neoplasms/*genetics
EDAT- 1999/04/22 02:04
MHDA- 2000/06/20 09:00
CRDT- 1999/04/22 02:04
PHST- 1999/04/22 02:04 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/04/22 02:04 [entrez]
AID - 10.1002/(SICI)1096-9896(199811)186:3<225::AID-PATH176>3.0.CO;2-D [pii]
AID - 10.1002/(SICI)1096-9896(199811)186:3<225::AID-PATH176>3.0.CO;2-D [doi]
PST - ppublish
SO  - J Pathol. 1998 Nov;186(3):225-6. doi: 
      10.1002/(SICI)1096-9896(199811)186:3<225::AID-PATH176>3.0.CO;2-D.