PMID- 10212823
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20180607
IS  - 0213-3911 (Print)
IS  - 0213-3911 (Linking)
VI  - 14
IP  - 2
DP  - 1999 Apr
TI  - Antinuclear antibody-keratinocyte interactions in photosensitive cutaneous lupus 
      erythematosus.
PG  - 627-33
LID - 10.14670/HH-14.627 [doi]
AB  - Autoimmune diseases are characterized by various circulating autoantibodies, 
      especially antinuclear antibodies (ANA). It has been a long-standing issue as to 
      whether and/or how ANA interact with epidermal cells to produce skin lesions. Of 
      these ANA, the anti-SS-A/Ro antibody is the most closely associated with 
      photosensitivity in patients with systemic lupus erythematosus (SLE) and its 
      subgroups, including subacute cutaneous lupus erythematosus (SCLE) and neonatal 
      lupus erythematosus (NLE). SS-A/Ro antigens are present in the nucleus and 
      cytoplasm, and interestingly, ultraviolet B (UVB) light translocates these 
      antigens to the surface of the cultured keratinocytes. Thus, anti-SS-A/Ro 
      antibodies in the sera can bind to the relevant antigens expressed on the 
      UVB-irradiated keratinocyte surface, and have been speculated to be an important 
      inducer of antibody-dependent keratinocyte damage. This interaction between the 
      anti-SS-A/Ro antibodies and UVB-irradiated keratinocytes may induce the skin 
      lesions through a cytotoxic mechanism. This review will focus on the involvement 
      of antibody-dependent cellular cytotoxicity in the pathogenesis of the skin 
      lesions observed in photosensitive cutaneous lupus erythematosus.
FAU - Furukawa, F
AU  - Furukawa F
AD  - Department of Dermatology, Hamamatsu University School of Medicine, Japan. 
      fukufuku@hama-med.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Antinuclear/*immunology
MH  - Autoantigens/metabolism
MH  - Humans
MH  - Keratinocytes/*immunology
MH  - Lupus Erythematosus, Cutaneous/*immunology/pathology
MH  - Ultraviolet Rays
RF  - 33
EDAT- 1999/04/23 00:00
MHDA- 1999/04/23 00:01
CRDT- 1999/04/23 00:00
PHST- 1999/04/23 00:00 [pubmed]
PHST- 1999/04/23 00:01 [medline]
PHST- 1999/04/23 00:00 [entrez]
AID - 10.14670/HH-14.627 [doi]
PST - ppublish
SO  - Histol Histopathol. 1999 Apr;14(2):627-33. doi: 10.14670/HH-14.627.