PMID- 10213157
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 263
IP  - 2-3
DP  - 1999 Mar 26
TI  - Decreased accumulation of endogenous brain-derived neurotrophic factor against 
      constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed 
      rats.
PG  - 149-52
AB  - Anterograde and retrograde trafficking of brain-derived neurotrophic factor 
      (BDNF) was examined in streptozotocin-diabetic and galactose-fed rats by 
      measuring accumulation of endogenous neurotrophin proximal and distal to two 
      constricting sciatic nerve ligatures and by direct injection of radiolabeled 
      neurotrophin into the sciatic nerve. Compared to controls, accumulation of 
      endogenous BDNF proximal and distal to the ligatures as well as basal levels in 
      non-ligated nerve segments were decreased in streptozotocin-diabetic and 
      galactose-fed rats. Neither streptozotocin diabetes nor galactose intoxication 
      affected the amount of 125I-labeled BDNF retrogradely transported to the DRG 
      after injection into the sciatic nerve. These results suggest that reduced 
      anterograde and retrograde accumulations of BDNF in experimental diabetes are not 
      a result of impaired capacity for receptor-mediated transport.
FAU - Mizisin, A P
AU  - Mizisin AP
AD  - Department of Pathology, University of California, San Diego, The Veterans 
      Administration Medical Center, La Jolla, USA. amizisin@ucsd.edu
FAU - DiStefano, P S
AU  - DiStefano PS
FAU - Liu, X
AU  - Liu X
FAU - Garrett, D N
AU  - Garrett DN
FAU - Tonra, J R
AU  - Tonra JR
LA  - eng
GR  - NS-32339/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iodine Radioisotopes)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Animals
MH  - Axonal Transport
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Diabetes Mellitus, Experimental/metabolism/*physiopathology
MH  - Female
MH  - Galactose/*toxicity
MH  - Ganglia, Spinal/metabolism/pathology/*physiopathology
MH  - Iodine Radioisotopes
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reference Values
MH  - Sciatic Nerve/metabolism/pathology/*physiopathology
EDAT- 1999/04/23 00:00
MHDA- 1999/04/23 00:01
CRDT- 1999/04/23 00:00
PHST- 1999/04/23 00:00 [pubmed]
PHST- 1999/04/23 00:01 [medline]
PHST- 1999/04/23 00:00 [entrez]
AID - S0304-3940(99)00131-7 [pii]
AID - 10.1016/s0304-3940(99)00131-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Mar 26;263(2-3):149-52. doi: 10.1016/s0304-3940(99)00131-7.