PMID- 10214874
OWN - NLM
STAT- MEDLINE
DCOM- 19990510
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 13
IP  - 4
DP  - 1999 Apr
TI  - Evaluation of minimal residual disease by interphase FISH in multiple myeloma: 
      does complete remission exist?
PG  - 641-4
AB  - As in other hematological malignancies, the achievement of a complete remission 
      (CR) is important in multiple myeloma but is still based on common cytological 
      and electrophoretic criteria. In this report, we studied 14 patients who achieved 
      an apparent CR following high-dose therapy using fluorescence in situ 
      hybridization (FISH) analysis. Although the results were difficult to interpret 
      in two patients, 12 of 14 patients had unequivocal persistence of abnormal plasma 
      cells in their bone marrow. Our results suggest that only a few patients, if any, 
      are in true CR following one course of high-dose therapy and are in favor of 
      post-transplantation treatments.
FAU - Genevieve, F
AU  - Genevieve F
AD  - Laboratoire d'Hematologie, Angers, France.
FAU - Zandecki, M
AU  - Zandecki M
FAU - Lai, J L
AU  - Lai JL
FAU - Hennache, B
AU  - Hennache B
FAU - Faucompre, J L
AU  - Faucompre JL
FAU - Stalnikiewicz, L
AU  - Stalnikiewicz L
FAU - Bauters, F
AU  - Bauters F
FAU - Facon, T
AU  - Facon T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Myeloma Proteins)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents, Alkylating/administration & dosage/therapeutic use
MH  - Bone Marrow/pathology
MH  - Chromosome Aberrations
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Male
MH  - Melphalan/administration & dosage/therapeutic use
MH  - Middle Aged
MH  - Multiple Myeloma/drug therapy/mortality/*pathology/therapy
MH  - Myeloma Proteins/analysis
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm, Residual
MH  - Neoplastic Stem Cells/pathology
MH  - Plasma Cells/pathology
MH  - Remission Induction
MH  - Survival Analysis
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - 10.1038/sj.leu.2401348 [doi]
PST - ppublish
SO  - Leukemia. 1999 Apr;13(4):641-4. doi: 10.1038/sj.leu.2401348.