PMID- 10215100
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20231213
IS  - 0301-0082 (Print)
IS  - 0301-0082 (Linking)
VI  - 57
IP  - 5
DP  - 1999 Apr
TI  - Nociceptin/orphanin FQ: role in nociceptive information processing.
PG  - 527-35
AB  - Recently, opioid receptor like1 (ORL1) receptor was identified. The ORL1 receptor 
      is a G protein coupled receptor and the sequence of the ORL1 receptor is closely 
      related to that of the opioid receptors. Nociceptin/orphanin FQ has been 
      identified as a potent endogenous agonist of the ORL1 receptor and the sequence 
      of nociceptin/orphanin FQ is closely related to that of dynorphin A. 
      Nociceptin/orphanin FQis not active at the classical opioid receptors, such as 
      mu, kappa and delta receptors. The distribution of prepronociceptin mRNA is 
      distinct from that of the opioid peptide precursor. Mice lacking the ORL1 
      receptor showed no significant differences in nociceptive threshold compared with 
      wild mice. The role of nociceptin/orphanin FQ on nociceptive transmission is 
      unclear. Intracerebroventricular (i.c.v.) injection of nociceptin/orphanin FQ 
      produced hyperalgesia and allodynia and antagonized morphine analgesia. On the 
      other hand, intrathecal injection of low dose nociceptin/orphanin FQ produces 
      allodynia, but high dose of nociceptin/orphanin FQ produces an analgesic effect. 
      Although we do not fully understand the mechanisms that produce the difference 
      between the effect of i.c.v. injection of nociceptin/orphanin FQ and that of 
      intrathecal injection of nociceptin/orphanin FQ, we believe that spinal ORL1 
      receptor may be the next receptor which should be targeted by drugs designed for 
      the treatment of pain.
FAU - Yamamoto, T
AU  - Yamamoto T
AD  - Department of Anesthesiology and Institute for Biochemical Science, School of 
      Medicine, Chiba University, Japan.
FAU - Nozaki-Taguchi, N
AU  - Nozaki-Taguchi N
FAU - Sakashita, Y
AU  - Sakashita Y
FAU - Kimura, S
AU  - Kimura S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Opioid Peptides)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Nociceptin Receptor)
SB  - IM
MH  - Analgesia
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Narcotic Antagonists
MH  - Opioid Peptides/pharmacology/*physiology
MH  - Pain/*physiopathology
MH  - Pain Threshold
MH  - Receptors, Opioid/*physiology
MH  - Spinal Cord/physiology/physiopathology
MH  - Transcription, Genetic
MH  - Nociceptin Receptor
MH  - Nociceptin
RF  - 89
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0301-0082(98)00067-7 [pii]
AID - 10.1016/s0301-0082(98)00067-7 [doi]
PST - ppublish
SO  - Prog Neurobiol. 1999 Apr;57(5):527-35. doi: 10.1016/s0301-0082(98)00067-7.