PMID- 10216181
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 825
IP  - 1-2
DP  - 1999 Apr 17
TI  - 5-HT2C receptor involvement in female rat lordosis behavior.
PG  - 146-51
AB  - Adult, hormone-primed, ovariectomized rats (CDF-344) with bilateral implants 
      within the ventromedial nucleus of the hypothalamus (VMN), were injected with 0.5 
      microgram estradiol benzoate followed 48 h later with 500 microgram progesterone. 
      This priming produced rats with 2 different levels of sexual receptivity. Rats 
      with a lordosis to mount ratio (L/M)>/=0.5 were used to examine the potential 
      lordosis-inhibiting effects of the 5-HT2A receptor antagonist, R(+)-a-(2, 
      3-dimethoxyphenyl)-1-[2(4-fluoro-phenylethyl)]-4-piperidine-methanol (MDL 
      100,907), and the 5-HT2C receptor antagonist, 
      5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2, 3-f]indole (SB 
      206553). Rats with low sexual receptivity (L/M<0.5) were bilaterally infused with 
      the 5-HT2A/2C receptor agonist, 
      (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or DOI plus either 
      MDL 100,907 or SB 206553 to determine if either drug would attenuate the 
      lordosis-facilitating effects of DOI. The 5-HT2C receptor antagonist, but not the 
      5-HT2A receptor antagonist, effectively inhibited lordosis behavior. Similarly, 
      SB 206553 was more effective than MDL 100,907 in reducing the DOI-induced 
      increase in lordosis responding. However, both drugs limited the duration of 
      lordosis responding initiated by DOI. These results are consistent with prior 
      suggestions that 5-HT2A/2C receptors within the VMN are involved in the 
      modulation of lordosis behavior and lead to the suggestion that 5-HT2C, rather 
      than 5-HT2A, receptors are primarily responsible for the effects of 5-HT2 
      receptor-active drugs on lordosis behavior.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Wolf, A
AU  - Wolf A
AD  - Department of Biology, Texas Woman's University, P.O. Box 425799, Denton, TX 
      76204-5799, USA.
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - DeLashaw, M
AU  - DeLashaw M
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - GM08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD 28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Fluorobenzenes)
RN  - 0 (Indoles)
RN  - 0 (Piperidines)
RN  - 0 (Pyridines)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 0 (dimethoxy-4-indophenyl-2-aminopropane)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4TI98Z838E (Estradiol)
RN  - 500-85-6 (Indophenol)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - AL4387525T (SB 206553)
RN  - EW71EE171J (volinanserin)
SB  - IM
MH  - Animals
MH  - Estradiol/analogs & derivatives/pharmacology
MH  - Female
MH  - Fluorobenzenes/pharmacology
MH  - Indoles/pharmacology
MH  - Indophenol/analogs & derivatives/pharmacology
MH  - Ketanserin/pharmacology
MH  - Ovariectomy
MH  - Piperidines/pharmacology
MH  - *Posture
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptor, Serotonin, 5-HT2C
MH  - Receptors, Serotonin/*physiology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Ventromedial Hypothalamic Nucleus/chemistry/drug effects/*physiology
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - S0006-8993(99)01159-2 [pii]
AID - 10.1016/s0006-8993(99)01159-2 [doi]
PST - ppublish
SO  - Brain Res. 1999 Apr 17;825(1-2):146-51. doi: 10.1016/s0006-8993(99)01159-2.