PMID- 10217303
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 72
IP  - 5
DP  - 1999 May
TI  - Stimulation of adenylyl cyclase and induction of brain-derived neurotrophic 
      factor and TrkB mRNA by NKH477, a novel and potent forskolin derivative.
PG  - 2198-205
AB  - The present study was undertaken to examine whether NKH477, a novel and potent 
      water-soluble forskolin derivative, stimulates adenylyl cyclase and regulates 
      brain-derived neurotrophic factor (BDNF) and TrkB expression in the rat brain. 
      Administration of NKH477 at a dose of 1.0 mg/kg, but not 0.1 mg/kg, increased 
      levels of cyclic AMP (cAMP) in a time-dependent manner in frontal cortex and 
      hippocampus. Repeated administration of NKH477 (1.0 mg/kg) for 7 or 14 days also 
      increased levels of cAMP in these two brain regions, indicating that the response 
      does not desensitize with chronic treatment. In addition, administration of 
      NKH477 at the 1 mg/kg dose increased the expression of BDNF and TrkB mRNA in 
      frontal cortex and hippocampus. This effect was observed after single, as well as 
      repeated (7 or 14 days), administration of NKH477. These results demonstrate that 
      NKH477 administration rapidly increases cAMP levels in brain and provides 
      evidence that stimulation of this second messenger system increases the 
      expression of BDNF and TrkB mRNA.
FAU - Morinobu, S
AU  - Morinobu S
AD  - Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
FAU - Fujimaki, K
AU  - Fujimaki K
FAU - Okuyama, N
AU  - Okuyama N
FAU - Takahashi, M
AU  - Takahashi M
FAU - Duman, R S
AU  - Duman RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 1F7A44V6OU (Colforsin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
SB  - IM
MH  - Adenylyl Cyclases/*metabolism
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Blotting, Northern
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Colforsin/*analogs & derivatives/pharmacology
MH  - Cyclic AMP/metabolism
MH  - Frontal Lobe/metabolism
MH  - Hippocampus/metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/*genetics
MH  - Time Factors
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0722198.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 May;72(5):2198-205. doi: 10.1046/j.1471-4159.1999.0722198.x.