PMID- 10217323
OWN - NLM
STAT- MEDLINE
DCOM- 19990622
LR  - 20220331
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 51
IP  - 2
DP  - 1999 Feb
TI  - Lavender oil inhibits immediate-type allergic reaction in mice and rats.
PG  - 221-6
AB  - We studied the effects of lavender oil on mast cell-mediated immediate-type 
      allergic reactions in mice and rats. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) 
      inhibited concentration-dependently mast cell-dependent ear swelling response 
      induced by compound 48/80 in mice by both topical and intradermal application. 
      Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently 
      passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by 
      both topical and intradermal application. Lavender oil (1:500, 1:100, 1:10, 1:1, 
      1:0) also inhibited concentration-dependently the histamine release from the 
      peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, lavender oil 
      (1:1000, 1:100, 1:10, 1:0) had a significant inhibitory effect on anti-DNP 
      IgE-induced tumour necrosis factor-alpha secretion from peritoneal mast cells. 
      These results indicate that lavender oil inhibits immediate-type allergic 
      reactions by inhibition of mast cell degranulation in-vivo and in-vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea.
FAU - Cho, S H
AU  - Cho SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Oils)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - ZBP1YXW0H8 (lavender oil)
SB  - IM
MH  - Anaphylaxis/etiology/prevention & control
MH  - Animals
MH  - Dinitrobenzenes/immunology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/chemically induced/*prevention & control
MH  - Immunoglobulin E/adverse effects
MH  - Lavandula
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Oils, Volatile/pharmacology/*therapeutic use
MH  - Peritoneum/cytology
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - *Plant Oils
MH  - Plants, Medicinal/chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Skin Diseases/etiology/prevention & control
MH  - Tumor Necrosis Factor-alpha/drug effects/metabolism
MH  - p-Methoxy-N-methylphenethylamine/adverse effects
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - 10.1211/0022357991772178 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1999 Feb;51(2):221-6. doi: 10.1211/0022357991772178.