PMID- 10218042
OWN - NLM
STAT- MEDLINE
DCOM- 19990428
LR  - 20191103
IS  - 1354-523X (Print)
IS  - 1354-523X (Linking)
VI  - 5
IP  - 1
DP  - 1999 Jan
TI  - The localization of matrix metalloproteinase-3 and tenascin in synovial membrane 
      of the temporomandibular joint with internal derangement.
PG  - 50-4
AB  - OBJECTIVES: The aim of this investigation was to study the immunohistochemical 
      localization of MMP-3 and tenascin in the temporomandibular joint and to compare 
      it with control specimens. MATERIALS AND METHODS: Localizations of matrix 
      metalloproteinase-3 (MMP-3) and tenascin in the temporomandibular joint disc and 
      the synovial membrane in 26 human temporomandibular joint samples (internal 
      derangement of TMJ; n = 16, and control; n = 10) by an immunohistological method 
      with monoclonal antibodies specific to human MMP-3 and tenascin. RESULTS: MMP-3 
      was not distributed in control specimens while it was observed in the internal 
      derangement cases. MMP-3 showed two staining profiles: (1) diffuse staining was 
      observed within the stroma of severely deformed disc with osteophyte and/or disc 
      displacement (three of 16 specimens); and (2) the localization was specifically 
      detected on the surface of severely hypertrophic synovial membrane (six of 16 
      specimens). The latter localization pattern resembled that of the tenascin on the 
      surface of the severely hypertrophic synovial membrane. CONCLUSION: Comparative 
      localization of MMP-3 and tenascin revealed intense staining for both in the 
      synovial membrane presenting inflammation, proliferation and hypertrophy. These 
      findings suggest that tissue repair and remodeling in the temporomandibular joint 
      disc and the inflammatory hypertrophic reaction in the synovial membrane might 
      proceed at the same time.
FAU - Yoshida, H
AU  - Yoshida H
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto 
      University, Japan.
FAU - Yoshida, T
AU  - Yoshida T
FAU - Iizuka, T
AU  - Iizuka T
FAU - Sakakura, T
AU  - Sakakura T
FAU - Fujita, S
AU  - Fujita S
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Joint Dislocations/*metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Middle Aged
MH  - Synovial Membrane/*metabolism
MH  - Synovitis/metabolism
MH  - Temporomandibular Joint/metabolism
MH  - Temporomandibular Joint Disc/*pathology
MH  - Temporomandibular Joint Disorders/*metabolism/pathology
EDAT- 1999/04/28 00:00
MHDA- 1999/04/28 00:01
CRDT- 1999/04/28 00:00
PHST- 1999/04/28 00:00 [pubmed]
PHST- 1999/04/28 00:01 [medline]
PHST- 1999/04/28 00:00 [entrez]
AID - 10.1111/j.1601-0825.1999.tb00064.x [doi]
PST - ppublish
SO  - Oral Dis. 1999 Jan;5(1):50-4. doi: 10.1111/j.1601-0825.1999.tb00064.x.