PMID- 10218672
OWN - NLM
STAT- MEDLINE
DCOM- 19990602
LR  - 20190905
IS  - 0193-1091 (Print)
IS  - 0193-1091 (Linking)
VI  - 21
IP  - 2
DP  - 1999 Apr
TI  - The cutaneous pathology associated with seropositivity for antibodies to SSA 
      (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous 
      lupus erythematosus.
PG  - 129-37
AB  - Antibodies to Ro/SSA are found in patients with subacute cutaneous lupus 
      erythematosus (SCLE), complement deficiency lupus erythematosus, systemic lupus 
      erythematosus (SLE), neonatal lupus erythematosus, and Sjogren syndrome (SS). 
      Most studies describing the cutaneous pathology associated with anti-Ro 
      antibodies have been of patients with SCLE. Over a 42-month period, we 
      encountered skin biopsy specimens from 23 anti-Ro-positive patients who did not 
      have SCLE: 15 had SLE variably manifesting as SCLE-like rashes; malar erythema; a 
      dermatomyositis-like rash; vascular disease involving cutaneous, cardiac, 
      peripheral, and central nervous systems; restrictive pulmonary disease; 
      periorbital edema; and myositis. Two patients had primary Sjogren syndrome, one 
      had primary antiphospholipid antibody syndrome, and two had rheumatoid arthritis; 
      all five had clinical evidence of cutaneous vasculopathy encompassing livedo, 
      perniosis, and palpable purpura. Three additional patients presented with 
      folliculocentric purpura without other stigmata to permit classification as a 
      specific connective tissue disease. In the SLE patients, biopsy specimens of 
      photodistributed eruptions showed an interface dermatitis accompanied by 
      superficial vascular plexus density reduction. Vasculopathic reactions in 
      patients with and without SLE comprised neutrophilic, lymphocytic, or 
      pauciinflammatory thrombogenic subtypes. Although at times a marker of SCLE, the 
      identification of anti-Ro antibodies may isolate a subset of patients at higher 
      risk of multiorgan vasculopathy, myositis, and progressive pulmonary disease. We 
      postulate that many of the features seen in these patients reflect the sequelae 
      of antibody mediated endothelial cell injury.
FAU - Magro, C M
AU  - Magro CM
AD  - Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson Medical 
      College, Philadelphia, Pennsylvania 19107-6799, USA.
FAU - Crowson, A N
AU  - Crowson AN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (SS-A antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antinuclear/*analysis/blood
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/metabolism/pathology
MH  - Lupus Erythematosus, Systemic/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Skin/chemistry/pathology
MH  - Skin Diseases/*metabolism/pathology
EDAT- 1999/04/28 00:00
MHDA- 1999/04/28 00:01
CRDT- 1999/04/28 00:00
PHST- 1999/04/28 00:00 [pubmed]
PHST- 1999/04/28 00:01 [medline]
PHST- 1999/04/28 00:00 [entrez]
AID - 10.1097/00000372-199904000-00004 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 1999 Apr;21(2):129-37. doi: 10.1097/00000372-199904000-00004.