PMID- 10219002
OWN - NLM
STAT- MEDLINE
DCOM- 19990510
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 54
IP  - 4
DP  - 1999 Apr
TI  - C4, BF, C3 allele distribution and complement activity in healthy aged people and 
      centenarians.
PG  - B150-3
AB  - The aim of this study was to examine the complement system and the distribution 
      of some human leukocyte antigen (HLA) class III alleles (C4, BF) in healthy aged 
      people (77 centenarians and 89 elderly subjects). We have also studied the 
      alleles of C3, a complement component genetically unrelated to HLA, the 
      immunochemical levels of C4 and C3 and serum functional hemolytic activity for 
      classical (CH50) and alternative (AP50) complement pathway. The levels of C3 and 
      C4 and the CH50 and AP50 were found to be within the normal range. The 
      frequencies of C3, BF, and C4A alleles were similar in the cohorts that have been 
      studied. For C4B null allele (C4BQ0) a trend toward an increase in the older 
      cohort was observed, although the differences were not significant after 
      statistical correction. Our data suggest that the complement system is well 
      preserved in centenarians and elderly subjects and class III HLA antigens are 
      equally distributed in aged cohorts and in young healthy individuals.
FAU - Bellavia, D
AU  - Bellavia D
AD  - Department of Immunology, University of Palermo, Italy.
FAU - Frada, G
AU  - Frada G
FAU - Di Franco, P
AU  - Di Franco P
FAU - Feo, S
AU  - Feo S
FAU - Franceschi, C
AU  - Franceschi C
FAU - Sansoni, P
AU  - Sansoni P
FAU - Brai, M
AU  - Brai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 0 (HLA Antigens)
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.21.47 (Complement Factor B)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics/immunology
MH  - *Alleles
MH  - Cohort Studies
MH  - Complement Activation/*genetics
MH  - Complement C3/analysis/*genetics
MH  - Complement C4/analysis/*genetics
MH  - Complement Factor B/analysis/*genetics
MH  - Complement Pathway, Alternative/genetics
MH  - Complement Pathway, Classical/genetics
MH  - DNA/genetics
MH  - Female
MH  - Gene Deletion
MH  - HLA Antigens/genetics
MH  - Hemolysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
EDAT- 1999/04/28 00:00
MHDA- 1999/04/28 00:01
CRDT- 1999/04/28 00:00
PHST- 1999/04/28 00:00 [pubmed]
PHST- 1999/04/28 00:01 [medline]
PHST- 1999/04/28 00:00 [entrez]
AID - 10.1093/gerona/54.4.b150 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):B150-3. doi: 
      10.1093/gerona/54.4.b150.