PMID- 10223430
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20190815
IS  - 0001-690X (Print)
IS  - 0001-690X (Linking)
VI  - 99
IP  - 4
DP  - 1999 Apr
TI  - Health care costs of therapy-refractory schizophrenic patients treated with 
      clozapine: a study in a community psychiatric service in Italy.
PG  - 274-80
AB  - This study evaluates the utilization of clozapine in the treatment of 
      therapy-refractory schizophrenia in terms both of patterns of care and of health 
      care costs in a community psychiatric service in Italy. Data covering the year 
      prior to commencing clozapine and the year following the initiation of the 
      therapy were collected. Clinical outcome was assessed by means of the Clinical 
      Global Impression (CGI) and Global Assessment of Functioning (GAF) scales. Cost 
      analysis followed a two-step procedure: (i) to record all health care services 
      provided to patients and (ii) to assign a monetary value to each service. Three 
      of the 15 patients enrolled in the study dropped out before the end of the 
      12-month period of therapy. Considering the 12 patients on clozapine treatment 
      for at least 1 year, clinical improvements are associated with a substantial 
      modification of the pattern of care. While patients in the pre-clozapine period 
      were mainly managed in hospital settings, patients on clozapine were prevalently 
      placed in the community and participated in intensive rehabilitative programmes. 
      The higher costs of drug therapy and community services in the post-clozapine 
      period were more than offset by the lower costs of acute hospital care.
FAU - Percudani, M
AU  - Percudani M
AD  - Psychiatric Unit of Magenta, Hospital of Legnano, Milan, Italy.
FAU - Fattore, G
AU  - Fattore G
FAU - Galletta, J
AU  - Galletta J
FAU - Mita, P L
AU  - Mita PL
FAU - Contini, A
AU  - Contini A
FAU - Altamura, A C
AU  - Altamura AC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Adult
MH  - Clozapine/*therapeutic use
MH  - *Community Mental Health Services
MH  - Female
MH  - *Health Care Costs
MH  - Humans
MH  - Italy
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*drug therapy/*economics
EDAT- 1999/05/01 00:00
MHDA- 1999/05/01 00:01
CRDT- 1999/05/01 00:00
PHST- 1999/05/01 00:00 [pubmed]
PHST- 1999/05/01 00:01 [medline]
PHST- 1999/05/01 00:00 [entrez]
AID - 10.1111/j.1600-0447.1999.tb07225.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 1999 Apr;99(4):274-80. doi: 
      10.1111/j.1600-0447.1999.tb07225.x.