PMID- 10223549
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20190831
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 58
IP  - 1
DP  - 1999 May
TI  - Fine mapping of an apparently targeted latent human herpesvirus type 6 
      integration site in chromosome band 17p13.3.
PG  - 69-75
AB  - An unusually high level of latent HHV-6 infection has been documented in the 
      peripheral blood and/or bone marrow cells of a small group of patients with 
      predominantly malignant lymphoid disorders, and in at least one healthy 
      individual. We have shown previously in peripheral blood mononuclear cells 
      (PBMCs) of three patients, two with a history of lymphoma and one with multiple 
      sclerosis, a specific target site for latent integration of the full-length HHV-6 
      viral genome on the distal short arm of chromosome 17, in band p13.3. 
      Fluorescence in situ hybridization (FISH) procedures were used to map more 
      precisely the location of the viral integration site in one of those patients, 
      relative to two known oncogenes mapped previously, namely CRK, and the more 
      telomeric ABR oncogene. It is shown that the HHV-6 integration site is located at 
      least 1,000 kb telomeric of ABR, and is very likely to map close to or within the 
      telomeric sequences of 17p. This finding is significant given that human 
      telomeric-like repeats flank the terminal ends of the HHV-6 genome. Cytogenetic 
      studies showed evidence of karyotype instability in the peripheral blood cells 
      infected latently.
FAU - Morris, C
AU  - Morris C
AD  - Department of Pathology, Christchurch School of Medicine, New Zealand.
FAU - Luppi, M
AU  - Luppi M
FAU - McDonald, M
AU  - McDonald M
FAU - Barozzi, P
AU  - Barozzi P
FAU - Torelli, G
AU  - Torelli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (ABR protein, human)
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Oncogene Protein v-crk)
RN  - 0 (Proteins)
RN  - 0 (Retroviridae Proteins, Oncogenic)
SB  - IM
MH  - Binding Sites
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 17
MH  - GTPase-Activating Proteins
MH  - Genome, Viral
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Interphase
MH  - Karyotyping
MH  - Oncogene Protein v-crk
MH  - Proteins/genetics
MH  - Retroviridae Proteins, Oncogenic/genetics
MH  - *Virus Integration
MH  - *Virus Latency
EDAT- 1999/05/01 02:12
MHDA- 2000/06/20 09:00
CRDT- 1999/05/01 02:12
PHST- 1999/05/01 02:12 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/05/01 02:12 [entrez]
AID - 10.1002/(SICI)1096-9071(199905)58:1<69::AID-JMV11>3.0.CO;2-3 [pii]
AID - 10.1002/(sici)1096-9071(199905)58:1<69::aid-jmv11>3.0.co;2-3 [doi]
PST - ppublish
SO  - J Med Virol. 1999 May;58(1):69-75. doi: 
      10.1002/(sici)1096-9071(199905)58:1<69::aid-jmv11>3.0.co;2-3.