PMID- 1022419 OWN - NLM STAT- MEDLINE DCOM- 19770520 LR - 20131121 IS - 0011-4162 (Print) IS - 0011-4162 (Linking) VI - 18 IP - 5 DP - 1976 Nov TI - Immunoglobulin E, atopy, and nickel allergy. PG - 715-6, 20 AB - Statements in the literature as to whether a relation exists between atopy and nickel allergy are contradictory. I have attempted to make the diagnosis of the two states more stringent by using immunoglobulin E (IgE) determinations and serial dilution tests with nickel sulfate. The IgE determinations proved to be of less value in cases of pure eczema, and nonspecific (?) increases were sometimes observed. The incidence of family atopy was higher in other reports, but the clinical significance of this was unclear. Serial dilution tests gave important information, and a warning is issued against uncritical acceptance of a test reaction with 5.0% nickel sulfate in a patient with suspected atopy. FAU - Wahlberg, J E AU - Wahlberg JE LA - eng PT - Journal Article PL - United States TA - Cutis JT - Cutis JID - 0006440 RN - 37341-29-0 (Immunoglobulin E) RN - 7OV03QG267 (Nickel) SB - IM MH - Dermatitis, Atopic/genetics/*immunology MH - Dermatitis, Contact/*etiology MH - Humans MH - Immunoglobulin E/*analysis MH - Nickel/*adverse effects EDAT- 1976/11/01 00:00 MHDA- 1976/11/01 00:01 CRDT- 1976/11/01 00:00 PHST- 1976/11/01 00:00 [pubmed] PHST- 1976/11/01 00:01 [medline] PHST- 1976/11/01 00:00 [entrez] PST - ppublish SO - Cutis. 1976 Nov;18(5):715-6, 20.