PMID- 10226528
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 1A
DP  - 1999 Jan-Feb
TI  - Chromosome 17 abnormalities in squamous cell carcinoma of the oral cavity, and 
      its relationship with p53 and Bcl-2 expression.
PG  - 81-6
AB  - Numerical aberrations of chromosome 17 were studied by fluorescence in situ 
      hybridization (FISH) using pericentromere specific DNA probe in 27 oral squamous 
      cell carcinomas (SCCs), and its relationship with p53 and Bcl-2 protein 
      expression was investigated. Since cells with polysomy 17 are significantly 
      increased in SCC (p = 0.0005), chromosome 17 abnormality seems to be correlated 
      with carcinogenesis of oral SCC. Chromosome 17 abnormality varied from case to 
      case, and the degree of the abnormality did not correlate with the stage of the 
      disease, the histological differentiation of SCC, or relapse of the disease and 
      lymph node metastasis. However, there was a correlation between polysomy 17 and 
      p53 immunoreactivity (p = 0.0228). p53 immunoreactivity showed a correlation with 
      relapse of the disease (p = 0.0441). An inverse relationship was found between 
      p53 and Bcl-2 immunoreactivity (p = 0.0421). In conclusion, we suggest that 
      polysomy 17 is closely related carcinogenesis of oral SCC, and with p53 
      overexpression. It is assumed that polysomy 17 correlates with the mutation of 
      p53 which results in an accumulation of aberrant p53 protein, and that its 
      activation causes an increase of p53 protein.
FAU - Kanekawa, A
AU  - Kanekawa A
AD  - Division of Oral and Maxillofacial Surgery, Yamaguchi Prefectural Central 
      Hospital, Hofu, Japan.
FAU - Tsuji, T
AU  - Tsuji T
FAU - Oga, A
AU  - Oga A
FAU - Sasaki, K
AU  - Sasaki K
FAU - Shinozaki, F
AU  - Shinozaki F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/chemistry/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/chemistry/*genetics
MH  - Proto-Oncogene Proteins c-bcl-2/*analysis
MH  - Tumor Suppressor Protein p53/*analysis
EDAT- 1999/05/05 00:00
MHDA- 1999/05/05 00:01
CRDT- 1999/05/05 00:00
PHST- 1999/05/05 00:00 [pubmed]
PHST- 1999/05/05 00:01 [medline]
PHST- 1999/05/05 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Jan-Feb;19(1A):81-6.