PMID- 10228803
OWN - NLM
STAT- MEDLINE
DCOM- 19990623
LR  - 20161124
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 46
IP  - 25
DP  - 1999 Jan-Feb
TI  - A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum 
      accompanied with multiple endocrine neoplasia type 1.
PG  - 257-60
AB  - A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum 
      accompanied by multiple endocrine neoplasia type-1 (MEN-1) is reported. A 46 
      year-old female underwent distal gastrectomy due to gastric ulcer 5 years ago. As 
      ulceration of the residual stomach recurred, further examination was performed. 
      Hyperprolactinemia, hypergastrinemia, primary hyperparathyroidism, pancreatic 
      tumor, and duodenal carcinoid were evident, and the diagnoses of 
      Zollinger-Ellison syndrome and MEN-1 were established. The origin of the gastrin 
      secretion was suspected to be from the pancreatic tumor, so sampling of the 
      portal blood was performed. As lesion on the gastrinoma in the pancreas could not 
      be identified, total parathyroidectomy was performed for primary 
      hyperparathyroidism. The level of the gastrin secretion, however, remained high. 
      Partial resection of the duodenum for the duodenal carcinoid and a distal 
      pancreatectomy were carried out concurrently. Immunohistochemical study of the 
      anti-gastrin antibody revealed duodenal tumor cells. Initially, the gastrinoma 
      was thought to be in the pancreas, however, the lesion accompanied with MEN-1 and 
      the Zollinger-Ellison syndrome had occurred in the duodenum.
FAU - Yazawa, K
AU  - Yazawa K
AD  - Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
FAU - Kuroda, T
AU  - Kuroda T
FAU - Watanabe, H
AU  - Watanabe H
FAU - Shimozawa, N
AU  - Shimozawa N
FAU - Nakata, S
AU  - Nakata S
FAU - Fujimori, Y
AU  - Fujimori Y
FAU - Koide, N
AU  - Koide N
FAU - Koike, S
AU  - Koike S
FAU - Kajikawa, S
AU  - Kajikawa S
FAU - Adachi, W
AU  - Adachi W
FAU - Amano, J
AU  - Amano J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Gastrins)
SB  - IM
MH  - Duodenal Neoplasms/*complications/diagnostic imaging/surgery
MH  - Female
MH  - Gastrinoma/*complications/diagnostic imaging/surgery
MH  - Gastrins/blood
MH  - Humans
MH  - Hyperparathyroidism/surgery
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Pancreatectomy
MH  - Parathyroidectomy
MH  - Tomography, X-Ray Computed
MH  - Zollinger-Ellison Syndrome/*etiology
EDAT- 1999/05/06 00:00
MHDA- 1999/05/06 00:01
CRDT- 1999/05/06 00:00
PHST- 1999/05/06 00:00 [pubmed]
PHST- 1999/05/06 00:01 [medline]
PHST- 1999/05/06 00:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 1999 Jan-Feb;46(25):257-60.