PMID- 10228824
OWN - NLM
STAT- MEDLINE
DCOM- 19990623
LR  - 20161124
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 46
IP  - 25
DP  - 1999 Jan-Feb
TI  - Perioperative changes in hepatic function as assessed by asialoglycoprotein 
      receptor indices by technetium 99m galactosyl human serum albumin.
PG  - 369-75
AB  - BACKGROUND/AIMS: Perioperative changes in intrinsic hepatocyte function and 
      functional volume were investigated. METHODOLOGY: 52 cases of liver cancer, 
      including hepatocellular carcinoma, cholangiocellular carcinoma and metastatic 
      carcinoma were studied. There were diagnoses of liver cirrhosis, liver fibrosis 
      and normal liver in 20, 23 and 9 cases, respectively. Hepatic resection of 
      subsegment, one segment, two segments and three segments were performed in 11, 6, 
      23 and 4 cases, respectively, while 8 cases were diagnosed as inoperable. 
      Assessments were performed before and 4 weeks after hepatectomy with 
      asialoglycoprotein (ASGP) receptor indices, i.e., technetium-99m-galactosyl human 
      serum albumin (TcGSA) uptake by the liver, TcGSA retention in the blood and 
      functional volume as measured by single emission computed tomography (SPECT) with 
      TcGSA as a probe. RESULTS: The hyperbolic relationship between galactosyl human 
      serum albumin (GSA) uptake by the liver and GSA retention in the blood, both of 
      which were independent of functional volume, shifted to the right after 
      hepatectomy. The number of conventional liver function tests correlating to the 
      GSA uptake increased after hepatectomy. By contrast, none of the pre-operative 
      and post-operative tests were correlated with functional volume. Post-operative 
      decrease in intrinsic hepatocyte function can be minimized by selection of mode 
      of hepatic resection. CONCLUSIONS: These results indicate that GSA uptake by the 
      liver can reveal information regarding intrinsic liver function which 
      deteriorates and becomes a decisive factor after hepatectomy.
FAU - Tanaka, A
AU  - Tanaka A
AD  - Department of Surgery, Kyoto City Hospital, Japan.
FAU - Shinohara, H
AU  - Shinohara H
FAU - Hatano, E
AU  - Hatano E
FAU - Sato, S
AU  - Sato S
FAU - Kanazawa, A
AU  - Kanazawa A
FAU - Yamaoka, Y
AU  - Yamaoka Y
FAU - Torizuka, T
AU  - Torizuka T
FAU - Konishi, J
AU  - Konishi J
FAU - Tamaki, N
AU  - Tamaki N
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Asialoglycoprotein Receptor)
RN  - 0 (Asialoglycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Technetium Tc 99m Aggregated Albumin)
RN  - 0 (technetium Tc 99m DTPA-galactosyl-human serum albumin)
RN  - VW78417PU1 (Technetium Tc 99m Pentetate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asialoglycoprotein Receptor
MH  - Asialoglycoproteins/*metabolism
MH  - Carcinoma, Hepatocellular/diagnostic imaging/physiopathology/surgery
MH  - Cholangiocarcinoma/diagnostic imaging/physiopathology/surgery
MH  - Female
MH  - *Hepatectomy
MH  - Humans
MH  - Liver/cytology/*diagnostic imaging/*physiopathology
MH  - Liver Cirrhosis/diagnostic imaging/etiology
MH  - Liver Function Tests/methods
MH  - Liver Neoplasms/*diagnostic imaging/*physiopathology/secondary/surgery
MH  - Male
MH  - Middle Aged
MH  - Receptors, Cell Surface/*metabolism
MH  - Technetium Tc 99m Aggregated Albumin
MH  - Technetium Tc 99m Pentetate
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 1999/05/06 00:00
MHDA- 1999/05/06 00:01
CRDT- 1999/05/06 00:00
PHST- 1999/05/06 00:00 [pubmed]
PHST- 1999/05/06 00:01 [medline]
PHST- 1999/05/06 00:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 1999 Jan-Feb;46(25):369-75.