PMID- 10228825
OWN - NLM
STAT- MEDLINE
DCOM- 19990623
LR  - 20161124
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 46
IP  - 25
DP  - 1999 Jan-Feb
TI  - Systemic effects of ethanolamine oleate in analbuminemic rats.
PG  - 376-80
AB  - BACKGROUND/AIMS: The present study was an attempt to clarify whether only serum 
      albumin inactivates ethanolamine oleate (EO) in vivo and whether EO has an 
      adverse effect on the lung, kidney, and liver in the presence of analbuminemia. 
      METHODOLOGY: Fifty-five female Nagase Analbuminemia Rats (NAR) and 55 female 
      Sprague-Dawley Rats (SDR) were injected with 5% EO in the left femoral vein. 
      Changes in respiratory, renal, and hepatic function and the extent of hemolysis 
      following the injection of the EO were examined. RESULTS: In both groups, a 
      transient but significant increase was seen in serum hemoglobin at up to 1 hour 
      after injection of EO. No significant changes in PaO2, PaCO2, blood urea 
      nitrogen, or serum creatinine following injection of EO were seen in either 
      group. The total bilirubin significantly increased within 30 min in the SDR 
      group, but this increase was prolonged for 5 days in the NAR group. Glutamic 
      pyruvic transaminase (GPT) increased for 12 hours in the NAR group, while no 
      change was seen in the SDR group. CONCLUSIONS: These observations suggest that EO 
      may have hepatotoxic effects, that serum albumin may afford protection, and that 
      other humoral substances which inactivate EO, including serum globulin, may be 
      present.
FAU - Kishihara, F
AU  - Kishihara F
AD  - Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
FAU - Ohta, M
AU  - Ohta M
FAU - Hashizume, M
AU  - Hashizume M
FAU - Tomikawa, M
AU  - Tomikawa M
FAU - Kawanaka, H
AU  - Kawanaka H
FAU - Tanoue, K
AU  - Tanoue K
FAU - Higashi, H
AU  - Higashi H
FAU - Sugimachi, K
AU  - Sugimachi K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Oleic Acids)
RN  - 0 (Serum Albumin)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - U4RY8MRX7C (ethanolamine oleate)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Female
MH  - Hemolysis
MH  - Kidney/*drug effects
MH  - Liver/*drug effects
MH  - Lung/*drug effects
MH  - Oleic Acids/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*pharmacology
EDAT- 1999/05/06 00:00
MHDA- 1999/05/06 00:01
CRDT- 1999/05/06 00:00
PHST- 1999/05/06 00:00 [pubmed]
PHST- 1999/05/06 00:01 [medline]
PHST- 1999/05/06 00:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 1999 Jan-Feb;46(25):376-80.