PMID- 10229328
OWN - NLM
STAT- MEDLINE
DCOM- 19990525
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 23
IP  - 4
DP  - 1999 Apr
TI  - Identification of multiple copies of a 20q-chromosome in a case of 
      myelodysplastic syndrome: a FISH study.
PG  - 407-13
AB  - In myelodysplastic syndromes (MDS) karyotypic aberrations identify subgroups of 
      patients with distinct clinical-morphological features and can be relevant in 
      risk assessment of developing leukemia. Often conventional cytogenetic analysis 
      is not sufficiently informative due to the presence of partially or completely 
      unrecognizable chromosome markers. By chromosome microdissection (MD) and 
      fluorescence in situ hybridization (FISH) we investigated the nature of a 
      karyotypic marker occurring in multiple copies in one case of MDS arisen in a 
      patient previously treated for breast cancer. Results showed dicentrics derived 
      from telomeric fusion between interstitially deleted 20q-chromosomes. The 
      abnormal karyotype resulted into polysomy for a deleted chromosome 20q.
FAU - Falzetti, D
AU  - Falzetti D
AD  - Hematology and Bone Marrow Transplantation Unit, University of Perugia, 
      Policlinico Monteluce, Italy.
FAU - Vermeesch, J R
AU  - Vermeesch JR
FAU - Hood, T L
AU  - Hood TL
FAU - Nacheva, E P
AU  - Nacheva EP
FAU - Matteucci, C
AU  - Matteucci C
FAU - Martelli, M F
AU  - Martelli MF
FAU - Van den Berghe, H
AU  - Van den Berghe H
FAU - Marynen, P
AU  - Marynen P
FAU - Mecucci, C
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosome Painting
MH  - *Chromosomes, Human, Pair 20
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 1999/05/06 00:00
MHDA- 1999/05/06 00:01
CRDT- 1999/05/06 00:00
PHST- 1999/05/06 00:00 [pubmed]
PHST- 1999/05/06 00:01 [medline]
PHST- 1999/05/06 00:00 [entrez]
AID - S0145212698001775 [pii]
AID - 10.1016/s0145-2126(98)00177-5 [doi]
PST - ppublish
SO  - Leuk Res. 1999 Apr;23(4):407-13. doi: 10.1016/s0145-2126(98)00177-5.