PMID- 10233012
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190124
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 276
IP  - 5
DP  - 1999 May
TI  - Mechanism of biphasic response of renal nerve activity during acute cardiac 
      tamponade in conscious rabbits.
PG  - R1232-40
LID - 10.1152/ajpregu.1999.276.5.R1232 [doi]
AB  - Renal sympathetic nerve activity (RSNA) responses to acute cardiac tamponade were 
      studied in conscious rabbits with all reflexes intact (Int) or after either 
      surgical sinoaortic denervation (SAD) or administration of intrapericardial 
      procaine (ip-Pro) or intravenous procaine (iv-Pro). In Int rabbits, the mean 
      arterial pressure (MAP) remained relatively constant until the pericardial volume 
      reached 7. 7 ml, whereas the RSNA increased to 226% [compensated cardiac 
      tamponade (CCT)], then, at a pericardial volume of 9.3 ml, the MAP fell sharply 
      and RSNA decreased to 34% [decompensated cardiac tamponade (DCT)]; 1 min after 
      cessation of pericardial infusion, an intravenous injection of naloxone resulted 
      in increases in both MAP and RSNA. In SAD rabbits, RSNA did not alter throughout 
      CCT and DCT, but increased on injection of naloxone. In ip-Pro rabbits, RSNA 
      increased during CCT but did not decrease during DCT, whereas, in iv-Pro rabbits, 
      the RSNA response was similar to that in Int rabbits. These results indicate that 
      RSNA responses to cardiac tamponade are biphasic, with an increase during CCT and 
      a decrease during DCT. Sinoaortic baroreceptors are involved in mediating the 
      increase in RSNA, whereas cardiac receptors may be involved in mediating the 
      decrease in RSNA. An endogenous opioid may be responsible for the decrease in 
      RSNA seen during DCT.
FAU - Hagiike, M
AU  - Hagiike M
AD  - Department of Surgery, Kagawa Medical University School of Medicine, Kagawa 
      761-0793, Japan.
FAU - Maeta, H
AU  - Maeta H
FAU - Murakami, H
AU  - Murakami H
FAU - Okada, K
AU  - Okada K
FAU - Morita, H
AU  - Morita H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Anesthetics, Local)
RN  - 0 (Narcotic Antagonists)
RN  - 36B82AMQ7N (Naloxone)
RN  - 4Z8Y51M438 (Procaine)
SB  - IM
MH  - Acute Disease
MH  - Anesthetics, Local/pharmacology
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Cardiac Tamponade/*physiopathology
MH  - Consciousness
MH  - Denervation
MH  - Heart/innervation
MH  - Heart Rate/physiology
MH  - Kidney/*innervation
MH  - Male
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Procaine/pharmacology
MH  - Rabbits
MH  - Reflex/physiology
MH  - Sympathetic Nervous System/drug effects/*physiopathology
EDAT- 1999/05/08 00:00
MHDA- 1999/05/08 00:01
CRDT- 1999/05/08 00:00
PHST- 1999/05/08 00:00 [pubmed]
PHST- 1999/05/08 00:01 [medline]
PHST- 1999/05/08 00:00 [entrez]
AID - 10.1152/ajpregu.1999.276.5.R1232 [doi]
PST - ppublish
SO  - Am J Physiol. 1999 May;276(5):R1232-40. doi: 10.1152/ajpregu.1999.276.5.R1232.