PMID- 10233873
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 93
IP  - 10
DP  - 1999 May 15
TI  - Chemotactic response toward chemokines and its regulation by transforming growth 
      factor-beta1 of murine bone marrow hematopoietic progenitor cell-derived 
      different subset of dendritic cells.
PG  - 3225-32
AB  - Dendritic cells (DCs) are highly specialized antigen-presenting cells that 
      distribute widely in all organs. DCs initiate the primary immune response and 
      activate naive T cells and B cells responsible for the acquired immunity. In this 
      study, CCR7 mRNA was proved to be expressed in DCs and their precursors derived 
      from murine bone marrow-derived hematopoietic progenitor cells (HPCs), whereas 
      CCR1 mRNA was expressed in both CD11b-/dullCD11c+ and CD11b+hiCD11c+ DC 
      precursors. CCR6 mRNA was not detected in any murine DC populations. In agreement 
      with the chemokine receptor mRNA expression by each population in the DC 
      differentiation pathway, SLC (also termed as MIP-3beta), one of the ligands for 
      CCR7, strongly and selectively chemoattracted both CD11b-/dullCD11c+ and 
      CD11b+hiCD11c+ DC precursors (days 6 to 7) and more mature DCs (days 13 to 14). 
      We have recently found that transforming growth factor-beta1 (TGF-beta1), a 
      cytokine that is essential for the appearance of Langerhans cells in the skin, 
      polarizes murine HPCs to generate Langerhans-like cells through 
      monocyte/macrophage differentiation pathway. We observed here that TGF-beta1 not 
      only inhibited the expression of CCR7 in DCs and DC precursors derived from HPCs, 
      but also inhibited the migration of these cells in response to SLC. This is the 
      first report describing the chemokine and chemokine receptors responsible for 
      murine DC migration and downregulation of DC migration by TGF-beta1.
FAU - Ogata, M
AU  - Ogata M
AD  - Department of Molecular Preventive Medicine and CREST, School of Medicine, The 
      University of Tokyo, Japan.
FAU - Zhang, Y
AU  - Zhang Y
FAU - Wang, Y
AU  - Wang Y
FAU - Itakura, M
AU  - Itakura M
FAU - Zhang, Y Y
AU  - Zhang YY
FAU - Harada, A
AU  - Harada A
FAU - Hashimoto, S
AU  - Hashimoto S
FAU - Matsushima, K
AU  - Matsushima K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD)
RN  - 0 (Ccr7 protein, mouse)
RN  - 0 (Macrophage-1 Antigen)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Stem Cell Factor)
RN  - 0 (Transforming Growth Factor beta)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Bone Marrow Cells/cytology/immunology
MH  - Cell Differentiation
MH  - Chemotaxis/drug effects/physiology
MH  - Dendritic Cells/classification/cytology/*immunology
MH  - Gene Expression Regulation/immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology
MH  - Hematopoietic Stem Cells/classification/cytology/*physiology
MH  - Macrophage-1 Antigen/analysis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Immunological
MH  - RNA, Messenger/genetics
MH  - Receptors, CCR7
MH  - Receptors, Chemokine/*genetics
MH  - Recombinant Proteins/pharmacology
MH  - Stem Cell Factor/*pharmacology
MH  - Transcription, Genetic
MH  - Transforming Growth Factor beta/pharmacology/*physiology
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
AID - S0006-4971(20)59551-7 [pii]
PST - ppublish
SO  - Blood. 1999 May 15;93(10):3225-32.