PMID- 10234361
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20190909
IS  - 0014-4800 (Print)
IS  - 0014-4800 (Linking)
VI  - 65
IP  - 3
DP  - 1999 Feb
TI  - The effect of red wine on experimental atherosclerosis: lipid-independent 
      protection.
PG  - 150-9
AB  - To assess the effect of red wine on atherosclerosis, New Zealand rabbits were 
      given 1% cholesterol diet for 12 weeks and compared to animals that received the 
      diet plus either red wine or nonalcoholic wine products (NAWP). Diet induced 
      marked increases in total and LDL cholesterol; yet no significant changes in HDL 
      and triglyceride concentrations occurred. In the control group, plaque area was 
      69 +/- 9% of the aortic surface, while in the wine and NAWP groups it was only 38 
      +/- 9 and 47 +/- 12%, respectively (P < 0.0001). The average intima/media 
      thickness ratio was 0.60 +/- 0.2 in control animals, 0.14 +/- 0.09 in the wine 
      group, and 0.39 +/- 0.19 in the NAWP group (P < 0.0001). No significant 
      differences were noted in LDL oxidizability among treatments. Thus, both red wine 
      and NAWP can prevent plaque formation in hypercholesterolemic rabbits despite 
      significant increases in LDL. We speculate that anti-platelet effect, blockade of 
      expression of endothelial cell adhesion molecules, and/or NO stimulation by red 
      wine flavonoids are possible explanations.
FAU - da Luz, P L
AU  - da Luz PL
AD  - Instituto do Caracao-Divisao de Clinica e Divisao de Experimentacao, Hospital das 
      Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Brazil.
FAU - Serrano Junior, C V
AU  - Serrano Junior CV
FAU - Chacra, A P
AU  - Chacra AP
FAU - Monteiro, H P
AU  - Monteiro HP
FAU - Yoshida, V M
AU  - Yoshida VM
FAU - Furtado, M
AU  - Furtado M
FAU - Ferreira, S
AU  - Ferreira S
FAU - Gutierrez, P
AU  - Gutierrez P
FAU - Pileggi, F
AU  - Pileggi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism/pathology
MH  - Arteriosclerosis/complications/*metabolism/pathology
MH  - Hypercholesterolemia/complications/metabolism/pathology
MH  - *Lipid Metabolism
MH  - Lipids/blood
MH  - Lipoproteins, LDL/blood
MH  - Rabbits
MH  - *Wine
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
AID - S0014-4800(99)80004-5 [pii]
AID - 10.1016/s0014-4800(99)80004-5 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 1999 Feb;65(3):150-9. doi: 10.1016/s0014-4800(99)80004-5.