PMID- 10319386
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20071115
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 36
IP  - 2
DP  - 1999 Apr
TI  - Genetics of small lymphocyte disorders.
PG  - 171-7
AB  - Cytogenetic analysis of small lymphocytes disorders is hindered by the low 
      mitotic activity of the malignant cells. The use of fluorescence in situ 
      hybridization (FISH) allows the detection of chromosomal amplifications, 
      deletions, or translocations at a single-cell level in dividing and resting 
      cells. The use of FISH in combination with other molecular techniques has defined 
      the deletion in band 13q14 as the most common abnormality in chronic lymphocytic 
      leukemia, followed by del (11)(q22-23), trisomy 12, del (17)(p13), and del 
      (6)(q21). The del 13q14 is also found in 70% of mantle-cell lymphomas (MCLs) and 
      in non-Hodgkin's lymphoma (NHL), acute lymphoblastic leukemia (ALL), and multiple 
      myeloma (MM) patients. These findings point to the existence of yet unidentified 
      tumor-suppressor gene(s) at the 13q14 locus, the loss/inactivation of which leads 
      to B-cell neoplasia. Del (17(p13) (involving the p53 tumor-suppressor gene) and 
      del (11)(q22-23) (involving the ataxia-telangiectasia gene [ATM]) seem to be 
      independent prognostic factors for poor survival in chronic lymphocytic leukemia 
      (CLL) patients. In MCL, the t(11;14) involving the bcl-1 gene is found, but data 
      from a bcl-1 transgenic animal model suggest that hyperexpression of bcl-1 is not 
      sufficient for lymphomatogenesis. Similar data are observed in bcl-2 transgenic 
      animals, a finding showing that the bcl-2 hyperexpression observed in 
      t(14;18)-positive follicular lymphoma cells is not sufficient to confer a 
      malignant phenotype. The contribution of other chromosomal abnormalities other 
      than bcl-1 and bcl-2 rearrangements in the pathogenesis of MCL and 
      follicular-cell lymphomas has to be determined.
FAU - Panayiotidis, P
AU  - Panayiotidis P
AD  - First Department of Propedeutic Medicine, University of Athens, Laikon Hospital, 
      Greece.
FAU - Kotsi, P
AU  - Kotsi P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - *Chromosome Aberrations
MH  - *Chromosome Disorders
MH  - Cyclin D1/genetics
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lymphoma/*genetics
MH  - Tumor Suppressor Protein p53/genetics
MH  - Waldenstrom Macroglobulinemia/*genetics
RF  - 77
EDAT- 1999/05/13 00:00
MHDA- 1999/05/13 00:01
CRDT- 1999/05/13 00:00
PHST- 1999/05/13 00:00 [pubmed]
PHST- 1999/05/13 00:01 [medline]
PHST- 1999/05/13 00:00 [entrez]
PST - ppublish
SO  - Semin Hematol. 1999 Apr;36(2):171-7.